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Portal > Offres > Offre UMR5048-FLOLEP-005 - Post-doctorat: Dissection mutationnelle systématique de génomes entiers H/F

Postdoctoral position: Deep mutational scanning of entire genomes

This offer is available in the following languages:
Français - Anglais

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General information

Reference : UMR5048-FLOLEP-005
Date of publication : Thursday, January 09, 2020
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 2 March 2020
Proportion of work : Full time
Remuneration : Monthly gross salary between €2643 and €4109 depending on experience
Desired level of education : PhD
Experience required : Indifferent


A 2-year post-doctoral position (1 year renewable) funded by the ATIP-Avenir program (CNRS-INSERM) is available to work in the “Synthetic, Functional and Evolutionary Genomics” group led by Guillaume Cambray at the Centre de Biochimie Structurale (CBS) in Montpellier, France.


Densoviruses could provide programmable biocontrol solutions against insects, though such applications must rest on comprehensive understanding. To achieve this, precise libraries encompassing all genomic point variants will be constructed via DNA synthesis. High-throughput multiplex screens based on deep-sequencing will be developed to extensively measure phenotypic consequences (replication, packaging, delivery, pathogenicity…). Data integration will enable reconstruction of functional and evolutionary landscapes for entire genomes.


The successful candidate should have a PhD in biology or related and a solid background in high-throughput synthetic biology, molecular evolution and/or virology. Dual experience with wet (molecular, cell biology) and dry (computer programing, statistical modeling) lab work will be strongly favored. The candidate should feel comfortable working in an interdisciplinary and international environment, be highly motivated and independent to take a strong lead on the project. Clear communication of scientific results through written scientific reports, oral presentations and attendance to scientific meetings is expected.

Work Context

The Centre de Biochimie Structurale (CBS) is an international institute offering a dynamic and stimulating scientific environment (13 teams, 140 persons, multiple nationalities; English is the working language). It provides state-of-the-art facilities, with a collaborative and lively atmosphere. Montpellier hosts a vibrant and diverse research community focusing on basic research, biomedicine, evolution and ecology. It is well connected to other major research areas. Montpelier is located a few kilometers from sea and mountains in the sunny South, offers a high quality of life and is one of the most attractive city in France.

Constraints and risks

For any questions about the project and the Lab, please contact Guillaume Cambray ( Candidates should send a brief statement of their research interests, their CV and up to 3 recommendation contacts. The position will begin in March 2020 at the earliest.

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