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Reference : UMR3571-PIECOR-001
Workplace : PARIS 15
Date of publication : Monday, November 19, 2018
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 7 January 2019
Proportion of work : Full time
Remuneration : 2600-3600
Desired level of education : PhD
Experience required : Indifferent
Postdoctoral position on “Investigation of pentameric ligand-gated ion channels by Voltage-Clamp fluorometry”. The channel-receptor group of the Institut Pasteur in Paris downtown is seeking highly motivated candidates for a postdoctoral position in electrophysiology to perform structure-function analysis in real time.
The successful candidate will be recruited for 12 months (renewable several times) funded by an ERC postdoctoral fellowship.
The proposed position concerns voltage-clamp fluorometry, to monitor the ion channel gating by electrophysiology concomitant with protein motions by fluorescence in physiological conditions. The project aims at developing innovative fluorescent labeling techniques, involving news dyes or unnatural amino acid, to develop original conformational sensors. It will also involve molecular biology, protein biochemistry and kinetic modeling.
Applicants are expected to have a degree in biology, biophysics, biochemistry or pharmacology, and a doctoral experience in electrophysiology. Previous experience in voltage-clamp fluorometry, as well as molecular biology or other fluorescence techniques will be a clear asset. The ideal candidate should be able to work independently but also feel comfortable working in an interdisciplinary environment, especially with structural biologists.
The work will be performed in the “Channel-receptors” team, under the supervision of Pierre-Jean Corringer. The team belong to the CNRS unit “genes synapses and cognition and to the neuroscience department of the Institut Passteur. The Institut Pasteur of Paris is internationally recognized and offers a highly dynamic social and scientific environment in the heart of Paris. Our lab studies the structure and function of pentameric ligand-gated ion channels, with a particular emphasis on understanding the structural bases of ion channel gating and regulation by small molecules. All projects in the lab are interdisciplinary in nature and combine structural techniques with functional approaches, including biochemistry, crystallography, pharmacology and electrophysiology, for which the lab is fully equipped. For more information on the Channel Receptor group, see (https://research.pasteur.fr/en/team/channel-receptors/)
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