Informations générales
Intitulé de l'offre : Engineer - Microfluidic Bioengineering for Cancer Research (M/F) (H/F)
Référence : UMR168-ELISIL-011
Nombre de Postes : 1
Lieu de travail : PARIS 05
Date de publication : mardi 24 juin 2025
Type de contrat : IT en contrat CDD
Durée du contrat : 12 mois
Date d'embauche prévue : 1 septembre 2025
Quotité de travail : Complet
Rémunération : Between €2,540.99 and €2,711.10 gross monthly depending on experience
Niveau d'études souhaité : BAC+5
Expérience souhaitée : Indifférent
BAP : A - Sciences du vivant, de la terre et de l'environnement
Emploi type : Ingenieure ou ingenieur biologiste en traitement de donnees
Missions
- Evaluate protocols for generating tumoroids using droplet-based microfluidics or microwell platforms
- Test anticancer therapies using these platforms, including chemotherapy and nanoparticle-based treatments
- Assess the risk-benefit profile of treatments in terms of tumor biomechanics and dissemination, particularly via the tumor secretome (including extracellular vesicles)
More precisely, we are looking for a lab engineer to work closely with a PhD student on a project in the field of nanomedicine, with a particular focus on photothermal therapy for cancer. The project partially involves the use of microfluidics to gain a deeper understanding of the effects of photothermal therapy in combination with other treatments.
The engineer's work will primarily focus on the biological aspects of the project. Key responsibilities will include conducting experiments on cancer cells, supporting microfluidic and photothermal therapy experiments, and performing data analysis.
Activités
• Master the use of droplet microfluidics platforms for spheroid formation
• Learn microfabrication protocols for spheroid generation
• Contribute to the development of tumoroid models incorporating tumor cell lines, cancer-associated fibroblasts, and potentially patient-derived xenografts (PDXs)
• Conduct chemotherapy tests, particularly sequential and combination therapies
• Test nanoparticle- and laser-based therapies, possibly in combination with chemotherapy
• Produce and characterize extracellular vesicles derived from tumoroids
Compétences
• Bioengineering
• Cell culture
Contexte de travail
The Physics of Cells and Cancer UMR168 laboratory offers a highly interdisciplinary and international working environment. It brings together experimental physicists, theorists, as well as biologists and biochemists, in the heart of the Latin Quarter in Paris.
Contraintes et risques
No particular constraints or risks.
Informations complémentaires
The position is funded for an initial period of one year, starting on September 1, 2025, with the possibility of renewal for an additional year.
Desired level of education: Master's degree
Desired experience: Shortly after graduation