Postdoctoral Researcher (M/F) in cell biology and neurosciences
New
- Researcher in FTC
- 12 months
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Protéinopathies du système nerveux
Contract Type
Researcher in FTC
Working hHours
Full Time
Workplace
94276 LE KREMLIN BICETRE
Contract Duration
12 months
Date of Hire
04/01/2027
Remuneration
from 3131€ gross per month
Apply Application Deadline : 09 November 2026 23:59
Job Description
Missions
A 12-month postdoctoral researcher position (renewable for an additional 12 months) is available to conduct research on the role of extracellular vesicles in the propagation of toxic proteins in Alzheimer's disease (AD) and Dementia with Lewy bodies (DLB). AD, DLB, and other related neurodegenerative disorders, share a common origin: the progressive invasion of the brain by abnormal protein deposits. The accumulation of these protein deposits in patients' brains involves cell-to-cell transfer of these abnormal proteins and their replication in a prion-like manner. This transport of abnormal proteins is notably mediated by extracellular vesicles (EVs), which are nanometric capsules secreted by all cells. The project aims to identify the molecular and functional signatures of AD- and DLB-specific EVs by combining biochemistry, cellular biology, and super-resolution microscopy approaches.
Activity
- Purification and characterization of extracellular vesicles from brain tissues and cerebrospinal fluid (CSF) (biochemistry, TRPS, electron microscopy).
- Quantitative analysis of subpopulations of EVs carrying toxic proteins (electron microscopy, SMLM, biochemistry).
- RT-QuIC assays for the amplification of pathological aggregates (biochemistry).
- Establishment of cellular models for the functional characterization of EVs carrying toxic proteins (cellular biology, electron microscopy, and super-resolution microscopy).
- Presentation of results and scientific article writing.
- Possible supervision of interns.
Your Profil
Skills
QUALIFICATIONS
- PhD in Cellular Biology, Biochemistry, or Neurosciences.
TECHNICAL SKILLS
- Expertise in extracellular vesicles purification (ultracentrifugation, SEC) and characterization (Western blots, TRPS, NTA, electron microscopy) methods.
- Expertise or basic knowledge in electron microscopy and/or super-resolution microscopy.
- Proficient in English.
KNOWLEDGE
- Strong interest and knowledge of extracellular vesicles (required).
- Interest in neurodegenerative diseases (desirable).
- Solid background in statistics and analytical methods.
SOFT SKILLS
- Scientific motivation and curiosity.
- Rigor and critical thinking.
- Teamwork and communication.
- Organization and autonomy.
- Compliance with hygiene and safety regulations.
Your Work Environment
The position is based within the "Extracellular Vesicles and Neurodegenerative Diseases" group, led by Dr. Mehdi Kabani, at the Neuro-Bicêtre Institute (INSERM U1195, CNRS EMR2000, Université Paris-Saclay, Le Kremlin-Bicêtre). This is a research center focused on proteinopathies and myelinopathies of the nervous system, bringing together academic researchers and clinicians. Our research projects are supported by Fondation Recherche Alzheimer, France Alzheimer, Fondation Alzheimer, Vaincre Alzheimer, Fédération pour la Recherche sur le Cerveau, A2MCL, and the ANR.
The postdoctoral researcher will have access to state-of-the-art equipment and required training for the project, including: TRPS (Tunable Resistive Pulse Sensing), Electron microscopes, Nanoscope for super-resolution microscopy, BSL-1 and BSL-2 labs.
Constraints and risks
- Handling of human biological tissues and fluids (Biosafety Level 2).
- Handling of prion-like proteins.
- Risks typically associated with biochemistry laboratory work (exposure to certain CMR substances under safety conditions imposed by CNRS, handling of liquid nitrogen with appropriate protections).
Compensation and benefits
Compensation
from 3131€ gross per month
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | EMR2000-MEHKAB-001 |
|---|---|
| CN Section(s) / Research Area | Cellular biology, development, evolution-development, reproduction |
| Relevant experience | 1 to 4 years |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
Create your alert
Don't miss any opportunity to find the job that's right for you. Register for free and receive new vacancies directly in your mailbox.