PhD "Micro-endoscopic probe for stimulated Raman histology" (M/F)
New
- FTC PhD student / Offer for thesis
- 36 months
- BAC+5
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Physique des lasers, atomes et molécules
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
59658 VILLENEUVE D ASCQ
Contract Duration
36 months
Date of Hire
01/01/2027
Remuneration
2300 € gross monthly
Apply Application Deadline : 16 November 2026 23:59
Job Description
Thesis Subject
Micro-endoscopic probe for stimulated Raman histology
Your Work Environment
Endoscopic techniques are essential for the diagnosis, staging and treatment of epithelial cancers. For many cancers, they are often the only way to access the tumour site directly. However, precancerous tissues sometimes exhibit subtle changes that cannot be detected visually. Endoscopic cancer detection has two main limitations: (1) the limited sensitivity of commonly used fluorescent markers and (2) the need for biopsies and histological analyses, which delay surgery and clinical decision-making.
This PhD project aims to develop a miniature optical probe for stimulated Raman histology able to provide real-time tissue images that closely match conventional histology (H&E staining). This approach aims to enable earlier and less invasive detection of gastroenterological cancers, while also exploring its potential for detecting urological cancers and assessing tumour margins during surgery.
We propose an innovative approach combining stimulated Raman scattering (SRS) microscopy, state-of-the-art hollow-core fibres, and advanced technologies for assembling miniature fibre-optic micro-endoscopic probes. The goal is to develop an SRS endoscopic probe capable of performing stimulated Raman histology in real time. The technology will be developed for applications in gastroenterological and urological cancers, with validation on relevant biological tissues in collaboration with clinical partners.
The PhD will be carried out at the PhLAM laboratory at the University of Lille, under the supervision of Alexandre Kudlinski, in close collaboration with Hervé Rigneault (Institut Fresnel, Aix-Marseille University) and Lightcore Technologies, a company based in Lille and Marseille.
This PhD project is strongly experimental in nature, focusing on optics, optical fibres, and ultrashort-pulse lasers. Skills in instrument control, electronics, optical design (particularly using software such as Zemax) and image processing would be an advantage. The candidate should have a strong interest in experimental optics, and demonstrate independence, initiative, and good practical problem-solving skills.
Constraints and risks
NA
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR8523-ALEKUD-009 |
|---|---|
| CN Section(s) / Research Area | Atoms and molecules, optics and lasers, hot plasmas |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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