M/F doctoral (PhD) position
New
- FTC PhD student / Offer for thesis
- 36 month
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Institut de Biologie Valrose
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
06108 NICE
Contract Duration
36 month
Date of Hire
01/10/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 20 July 2026 23:59
Job Description
Thesis Subject
This project aims to understand and harness the role of TREK potassium channels in pain control by developing two complementary strategies: a photopharmacological approach targeting TREK channels using the light-sensitive ligand LAKI (Landra--Willm et al., 2023), and Light-Induced Analgesia (Bied et al., 2026), a non-pharmacological method based on UV-A activation of endogenous channels. Together, these approaches provide a unique framework to remotely control channel function with high spatial and temporal precision.
Our objective is to dissect the cellular and circuit mechanisms operating in the peripheral nervous system and the spinal cord, where nociceptive information is first integrated and gated before reaching higher brain centers. We aim to determine how TREK channel activation shapes membrane excitability in primary afferents and dorsal horn neurons, how it alters synaptic transmission within spinal nociceptive circuits, and how these effects translate into changes in pain perception in vivo.
Your Work Environment
The Institute of Biology Valrose (http://ibv.unice.fr/EN/index.php) offers an international scientific environment, with approximately 300 individuals working across 27 research groups. The successful candidate will join the “Biology of Ion Channels” group to investigate the role of Two-Pore-Domain (K2P) potassium channels in pain perception.
Constraints and risks
NA
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR7277-GUISAN-017 |
|---|---|
| CN Section(s) / Research Area | Mathematics and mathematical interactions |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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