General information
Offer title : Postdoctoral Researcher (M/F) in Chemobiology (H/F)
Reference : UPR4301-LAELEG-056
Number of position : 1
Workplace : ORLEANS
Date of publication : 13 November 2025
Type of Contract : Researcher in FTC
Contract Period : 15 months
Expected date of employment : 12 January 2026
Proportion of work : Full Time
Remuneration : from 3 041,58 € gross monthly dependng on experience
Desired level of education : Doctorate
Experience required : 1 to 4 years
Section(s) CN : 16 - Chemistry of and for life: design and properties of molecules of biological interest
Missions
The successful candidate will be involved in a multidisciplinary research project aimed at developing polybodies – molecules with multiple recognition sites (peptides, haptamers) to target cellular receptors. These assemblies will then be evaluated in in vitro applications and in cell cultures.
Activities
Organic synthesis and bioconjugation.
Absorbance and fluorescence spectroscopy.
Biophysical studies (FIDA, BLI, ITC, NMR).
Cell culture, fluorescence microscopy, flow cytometry
Skills
Solid experience in organic chemistry and bioconjugation of biomolecules with reagents. Proficiency in molecular characterization techniques (NMR, MS, HPLC, UV/Vis, fluorescence). Good knowledge of molecular biophysics. Strong command of cell culture (cancer cells) and fluorescence microscopy. Organizational, adaptability, and innovative skills. Excellent command of English (reading and speaking comprehension, protocol and article writing). Critical review of literature
Work Context
The research team "Biophysics of Molecular Assemblies and Complex Systems (MACS)" is part of the CNRS UPR4301 unit "Center for Molecular Biophysics" located in Orléans. The team's interests cover a wide range of topics in the fields of synthetic chemistry and chemical biology, all grounded in molecular innovation. Our work involves the exploration of new chemical spaces as well as the development of multivalent molecules for therapeutic applications. The proposed position is part of a multidisciplinary project funded by the French National Research Agency (ANR) "Polyther," dedicated to the development of chemical/biochemical tools to combat cancer. This project is conducted in collaboration with teams at the CBM (Center for Molecular Biophysics) and a team at Université Paris-Saclay (Orsay).
Constraints and risks
The position involves exposure to chemical and biological risks, the management of which will be handled according to national regulations and the laboratory's internal rules. The person may be required to travel to other sites in the region and to Paris to collect data.