Missions

We are looking for a highly motivated Ingénieur.e d'Etude with a diploma in animal experimentation to join our team for 18 months in order to validate the anti-angiogenic activity of a monoclonal antibody that we have developed in different mouse models of ocular pathologies.

Activities

- Animal experimentation (Authorization to experiment with animals required)
- Perform tissue/molecular analyses of biological samples (histology, immunofluorescence staining, microscopy, etc…)
- Cellular / Molecular biology: Ensure activities requiring cell culture and/or molecular biology
- Analyze data, write and present progress reports
- Participation in the organization & coordination of the activity of the team

Skills

- General knowledge in biology, physiology
- Experimental knowledge of small animals and meet the regulatory requirements of the latter
- Previous work with murine models (accreditation for animal experimentation is required)
- Strong organizational skills
- Ability to work in a team

Work Context

The Cochin Institute (www.institutcochin.fr) is a Research Center (INSERM, CNRS, University Paris Cité) located in the campus of the Cochin Hospital, one of the most active Hospitals downtown Paris. Nine core facilities provide the scientists of the Institute with the most efficient technological support.
Our team, « Functional Pharmacology and Pathophysiology of Membrane Receptors» belonging to the department of "Metabolism and Endocrinology", uses pharmacological and biochemical approaches to understand the function of receptors, such as the G protein coupled receptors, the alteration of their regulation in pathology and evaluate their therapeutic potential. For this purpose, we combine both molecular and cellular studies that are complemented by the generation and study of different animal models. Our team is of international origin composed of about 15 members including 6 CNRS/INSERM researchers, postdoctoral researchers, PhD students and engineer.

Constraints and risks

This project will be carried out in collaboration with Team 14 (Inflammation, degeneration and vascular remodeling in retinal pathologies) of the Vision Institute and the candidate will have to share his/her working time between the 2 institutes.