Missions

Develop new tools for studying endogenous molecules in their cellular context. These tools will be designed to image the same protein complex using both fluorescence microscopy and (cryo-)electron microscopy, thereby revealing their ultrastructural organisation and enabling us to understand their functions.

Activities

The project aims to develop new molecular probes that will enable the direct study and monitoring of endogenous proteins in their original cellular environment. Protein engineering methods will then be used to generate probes from these specific molecular recognition modules, which will be used in different but complementary imaging modalities, ranging from super-resolution fluorescence microscopy to single-protein tracking techniques, including expansion microscopy and cryo-electron microscopy.

Skills

With a PhD in biotechnology, protein engineering and/or cellular imaging, this role requires:
•Protein engineering
•Cellular imaging

Work Context

Founded in 2011, the IINS brings together 180 scientists of different nationalities and backgrounds (chemistry, structural biology, molecular and cellular biology, biophysics, clinical medicine, advanced imaging, neurobiology) to understand how the brain functions in healthy and pathological states. The IINS conducts multidisciplinary research at the forefront of synaptic biology and neural system physiology, with a focus on developing new technologies and tools.

Constraints and risks

Possibility of working staggered hours