Missions

This position offers a unique opportunity to explore how RNA molecules shape cellular organization through phase separation, combining physics-based modeling with close collaboration across disciplines.

Activities

The postdoctoral researcher will develop and apply advanced multiscale simulation strategies, at both atomistic and coarse-grained resolutions, to investigate the molecular mechanisms of RNA-driven condensate formation and organization in cells. The goal is to elucidate the sequence–structure–function relationships that govern RNA-mediated phase separation and to explore how these principles can be harnessed to design programmable intracellular compartments for synthetic biology applications.

This research is conducted within the framework of the ANR SYNORG project (Transcriptionally Engineered Addressable RNA Solvent droplets as generalized synthetic organelles). The project will involve close interaction with experimental and computational partners, including Ariel Lindner (Université Paris Cité) and Sarah Berkemer (LIX, École Polytechnique).

Skills

We are looking for a motivated and focused researcher with a strong background in molecular modeling and its theoretical foundations. The ideal candidate should have a genuine interest in developing and applying simulation methods to address complex biological questions.

Essential qualifications are:
i) Proven experience in molecular simulations (atomistic and/or coarse-grained),
ii) Good programming/scripting skills (Python, C/C++ or similar),
iii) Solid understanding of the physical principles underlying molecular simulations (e.g., statistical mechanics, thermodynamics), and
iv) Motivation, curiosity, and a collaborative mindset.

Experience with modeling of RNA or biomolecular condensates and/or method development in molecular simulations will be considered an asset. The postdoctoral researcher will be encouraged to develop independent ideas and collaborations within and beyond the SYNORG consortium.

Work Context

The CBS (INSERM U1054, CNRS 5048, Université de Montpellier) is a leading centre for biophysics and structural biology, hosting state-of-the-art facilities for cryo-EM, advanced fluorescence and super-resolution microscopy, molecular and cell biology, and high-performance computing. Montpellier offers a vibrant international scientific community, an exceptional research environment, and a high quality of life in southern France.

Constraints and risks

Please upload your application containing:
1. A cover letter describing your background, research interests, and motivation
2. A CV including a list of publications
3. Contact details of two referees

Starting date as early as February 1st, 2026 (flexible).
Initial contract duration of 12 months, renewable for an additional 12 months