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Reference : UMR5203-JULKNI-001
Workplace : MONTPELLIER
Date of publication : Wednesday, June 14, 2017
Type of Contract : FTC Scientific
Contract Period : 36 months
Expected date of employment : 1 October 2017
Proportion of work : Full time work
Remuneration : 2500€ to 3500 € gross salary commensurated based on experience
Desired level of education : Doctorat
Experience required : Indifférent
The successful applicant will be in charge of the development of innovative tools to control mGlu4 activity based on the modification of nanobodies.
Design and perform experiments:
- Design and synthesis of photoactivable compounds
- Set up unnatural amino acids incorporation using prokaryotes
- Production, derivatization and characterization of nanobodies
- Analysis of pharmacological and signaling properties of the developed tools using heterologous expression system
- Validation on primary neuronal cultures
- Analysis and interpretation of the results
- Writing reports and oral communication of the results
- Management of technical staff and students
- Literature monitoring
- Expertise in molecular pharmacology, chemistry and biochemistry
- Former experience in organic synthesis or protein production is required
- Former experience in molecular pharmacology
- Former experience in primary neuronal culture and in signaling
IGF, the Montpellier Institute of Functional Genomics, is a CNRS-INSERM-University of Montpellier joint research center that develops innovative strategies and methods to explore the mechanisms involved in cell communication. The research programs cover from structural analysis of molecules to integrative biology and translational research, both in the fields of Neuroscience, Physiology and Cancer biology.
IGF welcomes about 250 people - researchers, professors, engineers, technicians, postdocs and students - working into the 22 research teams, five technological platforms and research support services.
Located within the University-Hospital campus 'Arnaud de Villeneuve', IGF provides a very dynamic and stimulating scientific environment. Montpellier is located in southern France by the Mediterranean see and enjoys quick access both to the beach and to hilly Cevennes region.
The successful applicant will work in the group “Neuroreceptors, dynamic and function” under the scientific supervision of a principal investigator (Julie Kniazeff) and the hierarchical direction of Jean-Philippe Pin. The group is composed of 5 PIs, 8 research assistants, 2 postdocs and 2 graduate students. This project is part of a collaborative work between IGF and the group of Amadeu Lleberia based in Barcelona (http://www.iqac.csic.es/mcs/) and supported by the “Fondation pour la Recherche Médicale” ((https://www.frm.org/chercheurs/les-appels-doffre/programme-espoirs-de-la-recherche).
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