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M/F - Proposal of a PhD position on the evaluation of potential effects induced by RadioFrequency and nanoparticles co-exposure on human cells

This offer is available in the following languages:
Français - Anglais

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General information

Reference : UPR8001-KATGRE-005
Workplace : TOULOUSE
Date of publication : Tuesday, June 23, 2020
Scientific Responsible name : K Grenier et E. Flahaut
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2020
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly

Description of the thesis topic

Context. Radiofrequency electromagnetic fields (RF) are widely used in civil and defense applications, for telecommunications, radar and electronic warfare in particular. Over the past decade, several collaborative research programs have been coordinated by WHO to assess the impact of these fields on the living. However, recent reports highlight a number of conflicting scientific results as well as strong questions about the consequences of exposure to RF waves on the living.

Abstract: Realized in partnership with an industrial, the PhD investigation focuses on evaluating the effects of RF waves associated with nanoparticles on human cells in culture. This will be performed through the use of specific metrologies, which ensures calibrated conditions of electromagnetic fields application. Different electrical stress parameters will be tested. This work will provide precise, quantitative data with respect to the dangers of non-ionizing electromagnetic radiation on the living.
This work will be co-supervised by K. Grenier and D. Dubuc from LAAS-CNRS and E. Flahaut from CIRIMAT-CNRS in order to get both RF exposure expertise and nanoparticle characterization and preparation expertise.

The PhD objectives are :
o The fabrication of components,
o The nanoparticles preparation,
o The characterization of nanoparticles,
o The experimental validation of cells RF exposures, including the evaluation of the Specific Absorption Rate -SAR- for different applied electromagnetic waves with the different metrologies (one at the single cell level, whereas the second one is used to expose cells suspensions),
o The synergistic tests including RF and nanoparticles exposures.

This project combines interdisciplinary competences in the fields of radio frequencies, electronic, chemistry and biology.

Profile : The candidate should present an electrical engineering or physical background, with a strong interest in interdisciplinary researchs.

Work Context

Location : LAAS-CNRS(MH2F team) and CIRIMAT-CNRS, Toulouse, France. The High Frequency and Fluidic Micro nanosystems team -MH2F- is located at LAAS in Toulouse, a CNRS laboratory, which has one of the 5 major micro- and nano-technologies clean room of France. Its expertise covers the miniaturization of RF systems as well as the operation of RF signals for new biological assay systems at the cellular and molecular level. The team is strongly involved in the committee dedicated to "Biological Effect and Medical Applications of RF and Microwave" of IEEE Microwave Theory and Techniques Society. The technical skills of members MH2F team cover the fields of design and RF metrology as well as of micro and nanotechnologies. Nanoparticles preparation and characterization are provided by CIRIMAT, a referenced lab for nanoparticle toxicity.

Constraints and risks

Electromagnetic waves are applied in near-field configurations. Therefore there is no encountered risk.

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