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AutoBioTip: Automation of mechanobiological measurements by AFM (M/F)

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : jeudi 1 juillet 2021

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General information

Reference : UPR8001-ETIDAG-003
Workplace : TOULOUSE
Date of publication : Thursday, June 10, 2021
Scientific Responsible name : Etienne Dague
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2021
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly

Description of the thesis topic

Autobiotip aims to bring AFM-Bio to large samples. The goal of this interdisciplinary thesis is to develop a method for automating force measurements that will allow to generate data on at least 1000 cells. Classical biophysical analyses and machine learning methods will then be adapted to extract mechanobiological information from the large amount of data generated in order to access the heterogeneity of cell populations.

Work Context

- The co-supervisor of the thesis, Etienne Dague, develops biophysical themes using AFM for the study of life. He is a member of the ELIA team at LAAS-CNRS and is the author of 80 publications (H index 33, >2875 citations). He was coordinator of an ANR JCJC project (2011-2014); leader of an interdisciplinary project team at ITAV-CNRS (2011-2016); coordinator of an IDEX transversality project (2015-2017); coordinator of an ANR CE42 AutoBioTip project (2021-2024).

- The co-director of the thesis, Childérick Severac, develops themes in instrumentation for mechanobiology within the RESTORE Laboratory and in the thematic field of tissue regeneration. He is a research engineer in charge of the MecanoBioFab of the Center of Expertise and Technological Resources and a member of the GOT-IT research team of RESTORE. He is the author of more than 45 scientific publications and 5 patents.

Within the Autobiotip project financed by the ANR, which constitutes the environment of this thesis project, the two thesis directors are associated because of their technical-scientific complementarity. Etienne Dague is responsible for the scientific coordination and Childérick Séverac is the coordinator for the RESTORE laboratory. More specifically, he is in charge of the scientific and technical developments related to the automation of the AFM. Moreover, as a member of the CERT team, he is in charge of the RESTORE's MecanoBioFab, and brings issues related to biophysics and biomechanics of cells and tissues with an opening to all the teams of the laboratory.

Constraints and risks

None

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