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Reference : UPR5301-ISACAL-073
Workplace : GRENOBLE
Date of publication : Tuesday, July 13, 2021
Scientific Responsible name : Issei Otsuka
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2021
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
Many compounds of biological interest such as amino acids and drugs have chiral structures on which rely their physiological properties. Hence, chiral separation is crucial and resolution of racemates by High Performance Liquid Chromatography (HPLC) equipped with polysaccharides-based chiral columns has been developed. Despite the impressive progress of the chiral HPLC, molecular level understanding of the phenomena at the origin of enantioseparation are lagging behind and thus, technologies suitable for large-scale separation have never been developed yet. This project ambitiously challenges both elucidation of the mechanism and development of a new technology for large-scale chiral separation by combining well-established theoretical and experimental analyses for the chiral separation via an innovative approach based on electrospun nanofibrous membranes made of various polysaccharides.
The project is based on an ongoing research project of Issei Otsuka (PhD supervisor, A2G team) concerning the effective chiral resolution of various racemic compounds using novel electrospun membrane filters. Some sub-themes of this main theme are funded by PolyNat in collaboration with CTP and CERMAV-Science in collaboration with the SPG team: Yoshiharu Nishiyama (thesis co-supervision), Yu Ogawa, and Karim Mazeau.
The candidate must have a solid background in polymer chemistry (synthesis and basic physicochemical characterizations such as NMR, IR, UV-vis, SEC, XRD, etc.).
Experience of electrospinning is preferred but not necessary. The candidate will be implicated in international collaboration projects (English communication required).
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