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PhD in Pharmaceutical formulation of dry powders for inhalation. (M/F)

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : vendredi 10 décembre 2021

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General information

Reference : UMR8612-NICTSA-001
Workplace : CHATENAY MALABRY
Date of publication : Friday, November 19, 2021
Scientific Responsible name : Nicolas TSAPIS
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 February 2022
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly

Description of the thesis topic

The emergence of pandemic respiratory viruses (e.g. SARS-CoV-2 coronavirus, some influenza A viruses (IAV),..) is a major concern. There is currently no effective anti-SARS-CoV-2 drug and the efficacy of anti-IAV antivirals is disputed. Vaccination is theoretically the best preventive strategy but is not necessarily sufficient to control these epidemics.
Our project aims to develop a metabolic therapy as a dry powder for inhalation based on (i) the fact that metabolites are now recognized as key effectors of the antimicrobial response and (ii) our identification of two metabolites with anti-IAV and anti-SARS-CoV2 antiviral activity. The candidate will develop formulations of these two metabolites as dry powders for inhalation, characterize them and determine their pharmacokinetics and biodistribution in healthy animals. Efficacy experiments on pathological models will be performed in collaboration.

Work Context

Experiments will be carried out at Institut Galien Paris-Saclay, a laboratory with expertise in pharmaceutical formulation. The PhD project will be performed in the Particle and Cell engineering team under the supervision of Nicolas TSAPIS. The team gathers multidisciplinary expertise of pharmacists, cemists, physical-chemists and biologists.

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