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PhD student (M/F) in organic and supramolecular chemistry

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Français - Anglais

Date Limite Candidature : jeudi 3 février 2022

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General information

Reference : UMR8612-ALIMAK-003
Workplace : CHATENAY MALABRY
Date of publication : Thursday, January 13, 2022
Scientific Responsible name : Ali Makky
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 7 February 2022
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly

Description of the thesis topic

The thesis project is part of the "joint call for projects" program between CNRS and the University of Toronto. The main objective of this thesis project consists in developping a new photo-activatable, multifunctional organic single component supramolecular assembly that can be used for the treatment of prostate cancer. Our strategy is to couple porphyrin or chlorin derivatives to phospholipid (PL) derivatives.
These PL-Por conjugates can self-assemble into lipid vesicle-like structures with well-ordered and compact porphyrin molecules. The intact assemblies possess significant photo-thermal properties (PTT). Moreover, the PL-Por conjugates can regenerate their photodynamic activity (PDT) in situ, after their dissociation into monomers in the tissues to be treated. Thus, these PL-Por allow a bimodal approach for the treatment of cancers that are easily accessible to light. In this approach combining photodynamic therapy and photothermal therapy, the photosensitisers are selected according to their capacity to generate reactive oxygen species when illuminated at a carefully chosen wavelength. The lipid backbones will be selected on the basis of their geometric stacking and their ability to allow the porphyrin derivatives to be arranged in a compact enough organization to enhance their PTT effect. The efficacy of these nanoassemblies will be tested in vitro and in vivo in orthotopic prostate cancer models.

Work Context

The Institut Galien Paris-Saclay (UMR CNRS 8612), founded in 1986, develops micro and nanotechnologies applied to medicine and diagnostics in the health field. The particularity of the unit is that it brings together researchers and teacher-researchers from different disciplines (chemistry, physical chemistry, galenics, chemical analysis and biology). The research themes are organised according to four major challenges:

1- Overcoming physiological barriers

2- Designing intelligent, programmable, activatable and biocompatible materials

3- Developing predictive models for the formation of new objects and their transport across biological barriers (tissue, cellular and subcellular)

4- Putting chemistry, physical chemistry and formulation at the service of diagnosis and imaging

To address these challenges, the Institut Galien Paris-Saclay has several platforms run by ITA/BIATSS (chromatographic analysis, cell culture, manipulation of radio elements, instrumentation workshop, molecular interactions, rheology). The attractiveness of the Institut Galien Paris-Saclay is attested by the large number of doctoral and post-doctoral students from all over the world that it attracts. Our unit hosts 3 members of the Institut Universitaire de France, 1 researcher benefiting from an ERC, 5 members of the Académie de Pharmacie and 1 member of the Académie des Sciences.

For more information about the research topics of the team:
http://www.umr-cnrs8612.universite-paris-saclay.fr/pres_eq1.php

Constraints and risks

For the successful completion of the thesis project and to strengthen the collaboration between the CNRS and the University of Toronto, the doctoral student must spend short periods of time at the University of Toronto (two to four weeks per year).

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