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Reference : UMR7357-MICGOR-003
Workplace : STRASBOURG
Date of publication : Wednesday, March 31, 2021
Scientific Responsible name : Michalina Gora
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 September 2021
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
The goal of the project is to develop a novel method to provide an in-vivo insight into the functioning of microbiota-gut-brain axis in small animals. The successful applicant will design and develop a novel endomicroscope that combines Optical Coherence Tomography (OCT) and optogenetics for mapping the morphology and the functionality of the enteric nervous system. This includes development of a multimodal optical system and micro-optical catheter for light delivery. This technology will be tested in bench-top and ex-vivo experiments with the ultimate goal of analysis of the gut's neuronal network status in small animals with various digestive conditions.
We are looking for an enthusiastic and autonomous candidate to participate in a highly interdisciplinary project that involves photonics, gastroenterology and neuroscience. The candidate must have excellent communication skills and experience in biomedical engineering, optical engineering, optical design and simulation, mechanical engineering, optomechatronics, medical robotics, vision, image processing or related fields. Familiarity with optical coherence tomography, optogenetics, confocal microscopy, endoscopic imaging, optical imaging systems for biomedical applications, image and signal processing will be a plus.
The project will be conducted in the research group of Dr. Michalina Gora that is hosted by CNRS and ICube Laboratory. The ICube laboratory brings together scientific communities coming from the areas of engineering, computer sciences and medical imaging. It provides access to various platforms with equipment that will be crucial to enable the project: including 3D multimaterial rapid prototyping system, the on-site pre-clinical platform with small animal MRI (7 Tesla Bruker Biospec 70/30 USR), fluorescence imaging and histology sectioning, animal anesthesia and monitoring system; 5 optical microscopes and a set of equipment for the development of photonic instrumentation. The team will be working closely with Dr. Laura Harsan who is the expert in optogenetic brain stimulation and fMRI imaging. In addition, Strasbourg offers a uniquely rich environment for translational and clinical research with many infrastructures and institutes that can assure the successful completion of the proposed project, such as institute in minimally invasive surgery IRCAD focused on the development of novel technologies for diagnostic and minimally invasive treatment and Institute of Cellular and Integrative Nurosciences.
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