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Reference : UMR6296-SOPROY-001
Workplace : AUBIERE
Date of publication : Wednesday, November 21, 2018
Scientific Responsible name : Sophie Faure
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 14 January 2019
Proportion of work : Full time
Remuneration : 1 768,55 € gross monthly
Description of the thesis topic
Title: Synthesis and study of peptoid-based tannin analogues as components in greener mineral wool binders
Originally developed in the early 1990s, peptoids are structurally related to peptides with the side chains located on the amide nitrogen atoms rather than the alpha-carbons. A major advantage of peptoids is their ease of synthesis, particularly by the straightforward “submonomer method” with huge side-chain diversity accessible. The peptoid group from the Chemistry Institute of Clermont-Ferrand (ICCF) develops alpha-peptoids and related peptoid family members such as beta-peptoids, alpha,beta-peptoids and arylopeptoids as peptidomimetics and scaffolds for ligand display. The group has acquired a strong expertise in solution-phase synthesis of linear and cyclic oligomers, the control of their architectures and the mimicry of naturally occurring compounds.
This research project will take place within the framework of an industrial collaboration with Rockwool International A/S (Denmark), the world's largest producer of stone wool. In the pursuit of greener stone wool products and related materials, Rockwool is developing new and greener binder systems based on various non-toxic biopolymers. A highly promising variant of these binder systems is based on gelatines modified with tannins. In order to increase the understanding of the role of the tannin component, this project is aimed at developping new peptoid-based tannin analogues as simplified mimics of these complex natural products. The PhD work includes the design, synthesis and characterization of peptoid-based tannin analogues at ICCF. These compounds will then be tested as components in the gelatin-based binders for mineral wool products at Rockwool International (Hedehusene, Denmark).
2. O. Roy, G. Dumonteil, S. Faure, L. Jouffret, A. Kriznik, C. Taillefumier J. Am. Chem. Soc., 2017, 139, 13533.
3. R. Shyam, N. Charbonnel, A. Job, C. Blavignac, C. Forestier, C. Taillefumier, S. Faure ChemMedChem, 2018, 13, 1513-1516 (DOI: 10.1002/cmdc.201800273).
5. T. Hjelmgaard, P. A. Thorsen, J. A. Bøtner, J. Kaurin, C. M. Schmücker, L. Nærum, Green Chem. 2018, 20, 4102-4111 (DOI: 10.1039/c8gc02021c).
The thesis project will be carried out at the Chemistry Institute of Clermont-Ferrand (ICCF UMR CNRS 6296)headed by Dr Fabrice Leroux in the research group “Peptoid” from the team “Medicinal and Organic Chemistry” managed by Pr Claude Taillefumier, and at the Rockwool binder research facility (Hedehusene, Denmark). The thesis will be conducted under the supervision of Dr Sophie Faure, head of the Peptoid group and co-supervised by Dr Thomas Hjelmgaard, scientific coordinator from Rockwool International.
Applicants should have a Master degree in Chemistry with good skills and a background in Organic synthesis. Experience in peptides or peptidomimetics synthesis and conjugation chemistry will be considered as an asset. Basic knowledge in material chemistry will be appreciated. Good relational skills are important for the project as it will be carried out in an interdisciplinary and international environment. Good communication skills (oral and written) in English and French are recommended.
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