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Reference : UMR5297-MELDES0-078
Workplace : BORDEAUX
Date of publication : Friday, October 8, 2021
Scientific Responsible name : Matthieu SAINLOS
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 December 2021
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
Development of biotechnological tools of protein nature by directed evolution and protein engineering in the context of the study of molecular mechanisms of synaptic transmission.
Design of directed evolution strategies mainly by phage display. Implementation of strategies (creation of libraries, screening, selections...) for the selection of clones with the desired properties. Implementation of methods for the validation of isolated clones by biochemical, biophysical and imaging methods. Engineering of protein tools by chemical or genetic methods.
Supervision and training.
Created on January 1, 2011, the Interdisciplinary Institute of Neuroscience (IINS) is a joint research unit attached to the CNRS and the University of Bordeaux.
With 160 people in 14 teams, IINS combines multidisciplinary skills to study the molecular and cellular mechanisms involved in brain activity. The Institute develops innovative methods in imaging, chemistry, physiology and computer science. As a component of Bordeaux Neurocampus, IINS is one of the major actors of the neuroscience community in Aquitaine.
Constraints and risks
Possibility of working shifts
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