By continuing to browse the site, you are agreeing to our use of cookies. (More details)

PhD student in neuroscience "TDeveloping a screening platform comprising" M/W

This offer is available in the following languages:
Français - Anglais

Ensure that your candidate profile is correct before applying. Your profile information will be added to the details for each application. In order to increase your visibility on our Careers Portal and allow employers to see your candidate profile, you can upload your CV to our CV library in one click!

Faites connaître cette offre !

General information

Reference : UMR5297-MELDES0-016
Workplace : BORDEAUX
Date of publication : Monday, September 09, 2019
Scientific Responsible name : Jean-Baptiste SIBARITA
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 November 2019
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly

Description of the thesis topic

The project aims at developing a screening platform comprising: i- a cutting-edge approach of 3D cell culture from pluripotent stem cells (iPSCs), combined with ii- a unique engineering technique for cellular microenvironment control and iii- an innovative soSPIM-based imaging technique allowing long term live 3D imaging of organoids coupled to morphogenetic image analysis.
Activities: Implement a screening platform dedicated to live 3D cell culture based on the soSPIM technology developed in the host laboratory (automated acquisition ans analysis workflow). Handle 3D cell culture models growth in dedicated microfabricated microwells.

Work Context

Established in January 2011, the Interdisciplinary Institute for Neuroscience (IINS) parent institutions are the CNRS (French National Center for Scientific Research) and the University of Bordeaux.
With 160 people and 12 research teams, IINS deploys multidisciplinary expertise to study molecular and cellular mechanisms involved in brain activity. The Institute develops innovative methods in imaging, chemistry, physiology and computer science. IINS is a major player in Aquitaine's neuroscience community and a leading component of Bordeaux Neurocampus and BRAIN, a cluster of excellence in Neuroscience.
The project will be mainly developed in the host laboratory in Bordeaux, but the PhD student will be exposed to international research. He will have to travel to Singapore to learn 3D cell culture and duplicate the screening platform.
The PhD student will be co-supervised by J.B. Sibarita in Bordeaux and V. Viasnoff in Singapore (MBI, UMI3639 CNRS). Both teams have a long standing and fruitful collaboration (7 years, 3 publications and 4 patents).

Constraints and risks

Work in moved schedule possible.

We talk about it on Twitter!