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Reference : UMR5248-PATDUL-009
Workplace : PESSAC
Date of publication : Monday, November 04, 2019
Scientific Responsible name : LOQUET
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 15 January 2020
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
The Nuclear Magnetic Resonance (NMR) group of the Institute of Chemistry and Biology of Membranes and Nanoobjects (CBMN UMR5248) in Pessac is proposing a doctoral contract funded by the CNIV (Comité National des Interprofessions des Vins à appellation d'origine et à indication géographique) and the Conseil Régional de la région Nouvelle Aquitaine to study molecular markers in vine wood by NMR spectroscopy. The 3-year project will study wood samples by NMR spectroscopy to establish a database to understand the biophysical processes involved in wood degradation
Among the factors responsible for the decline of the vine, wood diseases, i.e. esca, eutypiosis and cankers with Botryosphaeriaceae, have become in the space of twenty years the object of major concerns for the wine industry in France. Although the pathogenicity of fungi, epidemiology or host-pathogen interaction aspects have already been studied, the molecular causes of vine decline have yet to be determined. In particular, the evolution of the microstructure of vine wood from a healthy and structured state to a necrotic state has never been studied at the atomic level. This project proposes to develop an analytical approach combining very high field solid-state NMR spectroscopy and X-ray diffraction/diffusion to identify, characterize and understand molecular markers of vine wood dieback at the atomic scale.
The recruited candidate will participate in the study using NMR spectroscopy. Experience in this technique (NMR) as well as in the field of biophysics is an advantage.
Nuclear magnetic resonance spectroscopy, analysis of multidimensional NMR experiments, biophysical study
The project will be carried out at the Institute of Chemistry and Biology of Membranes and Nanoobjects in Pessac. The laboratory is located in the IECB building (European Institute of Chemistry and Biology). The CBMN Institute is a multidisciplinary institute at the interface between physics, chemistry and biology. It hosts 15 research teams and has a very large number of structural biophysics platforms (NMR, X-ray, MS, Vibration, AFM, etc.). The institute is equipped to perform NMR experiments and X-ray diffraction.
Constraints and risks
Experience in NMR spectroscopy. Additional biophysical skills will be appreciated.
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