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Reference : UMR5248-PASPAT-003
Workplace : PESSAC
Date of publication : Monday, November 25, 2019
Scientific Responsible name : P. Subra Paternault
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 2 March 2020
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
The formation of co-crystals (molecular assembly of two species) with compressed CO2 emerged only very recently. The objective of the thesis is to go above the proof of concept by focusing on time-related events that should control the nature of the produced crystals and the purity of the produced powders in cocrystals, two characteristics of primary importance for the targeted pharmaceutical applications. To address such kinetic aspects, the crystallization will be first studied in an innovative high-pressure CO2 microfluidic plateform where in-situ diagnostic will be implemented before scaling up to larger set-ups. The crystallization will be then applied to chiral resolution.
The candidate will work in a dynamic environment thanks to the co-working between CBMN that has the background in CO2-cocrystals and ICMCB's team specialist of microfluidic, and thanks to the framework of a national project that gathers specialists of conventional crystallization including with chiral molecules.
Constraints and risks
Handling of pressurized equipments
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