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Reference : UMR5237-ALECOP-003
Workplace : MONTPELLIER
Date of publication : Tuesday, October 5, 2021
Scientific Responsible name : Alenka Copic
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 December 2021
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
Phosphatidylserine is a negatively-charged phospholipid with a very uneven distribution in eukaryotic cells. In healthy cells, it is highly enriched in the cytosolic leaflet of the plasma membrane, where is it essential for controlling cell polarity and signalling reactions. The goal of this project is to study how PS gradient is established in cells by using the model system budding yeast, where we have recently shown that the PS transfer protein Osh6 cooperates with the membrane contact site protein Ist2 to deliver PS to the plasma membrane.
The Cell Biology Research Center of Montpellier (UMR 5237 between CNRS and the University of Montpellier) is organized in 16 research teams, technological platforms and common services, and counts about 150 people (researchers and teacher-researchers, engineers, technicians and administrative staff, PhD and post-doctoral students). The CRBM is connected with other institutes on the same campus where it shares different platforms, including the MRI imaging platform equipped with the most advanced microscopes and dedicated staff.
The PhD student (M/F) will integrate in the team of Alenka Copic "Cell biology of lipid storage and transfer". We use different cellular and biochemical models to understand how proteins control the storage and distribution of lipids in eukaryotic cells.
The project will be carried out in the context of an ANR PRC project ('MixAndMove') in collaboration with three other groups in France, which use biochemical, biophysical and modelling approaches.
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