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Reference : UPR5301-ISACAL-065
Workplace : GRENOBLE
Date of publication : Monday, January 11, 2021
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 March 2021
Proportion of work : Full time
Remuneration : between 2648.79 and 3768.24 € gross monthly depending on experience
Desired level of education : PhD
Experience required : 1 to 4 years
The ANR project “PULmarin” aims at ascribing function to polysaccharide utilization loci (PUL) identified in bacterial strains living in marine environment and in gut microbiome. The role of the applicant will be to participate in the biochemical characterization of targeted enzymes and to attribute a function to predicted PUL.
The applicant will produce recombinant enzymes (glycoside hydrolases, polysaccharides lyases, sulfatase) selected by our partner (CAZy members, AFMB Marseille). The targeted enzymes will be screened on a unique collection of polysaccharides available in the laboratory. The most interesting enzymes will be characterized by chromatography and spectroscopy methods in order to describe finely all the steps of the degradation of complex polysaccharides.
Diploma : phD/thèse
The applicant should have a good experience in molecular biology and protein expression (e.g. E. coli). Knowledges in polysaccharide and polysaccharide degradation enzymes are recommended. Due to the manipulation of a large data set, the applicant must demonstrate autonomy and rigor.
The Centre de Recherches sur les Macromolécules Végétales CERMAV-CNRS (Grenoble) is a fundamental research center devoted to Glycosciences, with strong and multidisciplinary expertise that spans from chemistry, physical-chemistry, biology to material sciences. All the facilities and expertises required for the achievement of the project are available in the laboratory.
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