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Reference : UPR3572-ISACLA-001
Workplace : STRASBOURG
Date of publication : Monday, January 11, 2021
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 May 2021
Proportion of work : Full time
Remuneration : From 2678,25 euros gross monthly according to experience
Desired level of education : PhD
Experience required : 1 to 4 years
One of the objectives of DIAGONAL European project (call H2020-NMBP-TO-IND-2018-2020) is to acquire knowledge on the physicochemical properties and the toxicological impact of commercial multicomponent nanomaterials and high aspect ratio nanoparticles, throughout their life cycle, in order to develop and apply the concept of "Safe-by-Design" to industrial products.
The study at I2CT will cover the in vitro impact of different multicomponent nanomaterials and high aspect ratio nanoparticles on immune cells, as well as the evaluation of their (bio)degradability.
The candidate must have a doctorate, or equivalent research experience, in nanomaterials, bionanotechnology, molecular biology, toxicology and related disciplines. He/she should have experience in cell culture, intracellular processes, flow cytometry, confocal microscopy, electron microscopy and statistical analysis.
The candidate should be independent, well organized and detail oriented. He/she should have good interpersonal skills and the ability to supervise Masters students. He/she must manage his own research and administrative activities, coordinate the different aspects of the work to meet deadlines. He/she should contribute with ideas for new research projects, conduct comprehensive and systematic literature reviews and compile the results for publication in peer-reviewed journals, present articles and posters. He/she must lead collaborative projects with colleagues from partner institutions and actively participate in laboratory meetings. He/she should also be available and willing to travel abroad for project meetings and research secondments.
This project will be developed at the Immunology, Immunopathology and Therapeutic Chemistry Unit (CNRS UPR 3572, I2CT), which belongs to the CNRS and is located at the Institute of Molecular and Cellular Biology of Strasbourg (France). Researchers at the I2CT address different aspects of therapeutic immunology, including the identification of the responsible for the immune response, the study of the mechanisms of this response and the development of synthetic molecules with relevant pharmacological properties. The objective is to define innovative ways of targeted immune interventions for the treatment of autoimmune and cancerous pathologies. A few years ago, the I2CT launched an innovative research program aimed at developing systems based on functionalized carbon materials for therapeutic and preventive biomedical applications, and for imaging. The immobilization of bioactive molecules on carbon and other materials allows the potential use of such conjugates for diagnostic purposes, for targeted cell recognition, or as drug delivery systems. To complement this work, an important activity concerns the impact of carbon materials and other materials on health and the environment.
Constraints and risks
There are no constraints. Biological and chemical risks
Candidates interested must send their application with cover letter, curriculum vitae and the contacts of three referents.
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