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Reference : UPR2301-CATGUI-002
Workplace : GIF SUR YVETTE
Date of publication : Friday, June 11, 2021
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 September 2021
Proportion of work : Full time
Remuneration : Programme funded by the Fondation pour la Recherche Médicale
Desired level of education : PhD
Experience required : 1 to 4 years
A post-doctoral contract is proposed within the framework of a project dealing with the study of drug candidates modulating the action of molecular motors involved in cancer. The candidate will be in charge of the synthesis of molecular motor modulators for in vitro and structural studies within an interdisciplinary programme. This recruitment is part of a project financed by the Foundation for Medical Research in collaboration between the "design, synthesis and evaluation of molecules of therapeutic interest" team led by Catherine Guillou (ICSN/CNRS UPR2301) and the "structural motility" team led by Anne Houdusse (Institut Curie/CNRS UMR144).
- Design, synthesis and characterisation of new bioactive compounds
-Purification and spectrometric analysis of synthesised compounds (NMR, Mass, HPLC, IR ..)
-Writing of reports and regular oral presentations
- Analysis of results
-Participation in the writing of articles and patents
- PhD in organic synthesis, medicinal chemistry, biological chemistry
- Good command of classical synthetic chemistry and spectroscopic analysis techniques (NMR, mass, HPLC)
- Experience in multi-step synthesis
- Strong interest in the chemistry-biology interface
- Strong motivation, a creative spirit and an ability to integrate into a multidisciplinary project.
- Ability to work effectively both independently and as part of a team
- Excellent oral and written communication skills
- Knowledge in medicinal chemistry, biological chemistry would be appreciated.
- Good level of scientific English (read, spoken and written)
The project will be carried out at the CNRS, at the Institute of Natural Product Chemistry (UPR 2301) located in Gif-sur-Yvette, in the Natural Products and Medicinal Chemistry Department, and more specifically within the "Design, synthesis and evaluation of molecules of therapeutic interest" team led by Catherine Guillou, Research Director at the CNRS
Constraints and risks
Work in organic chemistry with the usual constraints of organic chemistry (work in a ventilated fume cupboard, personal protective equipment, etc.)
Programme funded by the Fondation pour la Recherche Médicale
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