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Reference : UPR2301-ARNCHE-001
Workplace : GIF SUR YVETTE
Date of publication : Friday, October 04, 2019
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 10 January 2020
Proportion of work : Full time
Remuneration : Between 2 693,24 et 3 105,50 euros based on the experience (gross monthly)
Desired level of education : PhD
Experience required : Indifferent
Fluorescence imaging is constantly developing through the synthesis and use of molecules with optimized optical properties. Recent advances have enabled the emerging of fluorogenic technics for the enzymatic activity detection and have improved our understanding of the biological phenomena operating in the various compartments of the cell. The mission of the candidate will be to design and to synthetize new compounds that could extand the scope of detected enzyme activities and give access to their cellular location
The candidate will have to:
1. Multi-step synthesis of fluorescent compounds whose structure must fulfill the specifications dictated by the biological problems studied.
2. Their functionalisation to confer them fluorogenic properties in response (presence?) to various enzymatic activities.
The candidate must be able to design and execute the syntheses of targeted compounds, involving a large variety of chemistry (heterocyclic chemistry, palado-catalyzed coupling, click chemistry ...). Strong knowledge and practical experience as an organic chemist are essential for the realization of this project. Knowledge in analytical chemistry and optical characterization would be also appreciated.
The Institut de Chimie des Substances Naturelles is a proper Research Unit of the CNRS whose research focuses on chemistry and biology. It is part of the University Paris-Saclay which brings together, since 2015, research and teaching institutions in southern Paris. The ICSN is located on the campus of Gif-sur-Yvette and has about 150 agents including 80 permanent spread across 3 buildings. This work will be carried out within the Department of Chemical Biology and under the supervision of Dr. Arnaud CHEVALIER, CNRS researcher. https://icsn.cnrs.fr/recherche/cb
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