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Portal > Offres > Offre UMR9199-GILBON-001 - Postdoc (H/F) – Métabolisme des astrocytes et maladie d'Alzheimer

Postdoc – Astrocytes metabolism and Alzheimer Disease

This offer is available in the following languages:
Français - Anglais

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General information

Reference : UMR9199-GILBON-001
Workplace : FONTENAY AUX ROSES
Date of publication : Thursday, March 19, 2020
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 June 2020
Proportion of work : Full time
Remuneration : Gross salary: from 2600€ according to experience
Desired level of education : PhD
Experience required : 1 to 4 years

Missions

Post-doctoral researcher to join a research team led by Gilles Bonvento and working on the role of astrocytes in Alzheimer's disease. The neurodegenerative diseases laboratory is located at MIRCen at the CEA center in Fontenay-aux-Roses (5 km from Paris). The project funded by the Medical Research Foundation for 24 months is focused on the study of astrocyte energy metabolism in collaboration with the team of Serge Charpak at the Institute of Vision.

Activities

The project will combine several metabolic and electrophysiological imaging approaches. The successful candidate will:
- Carry out FRET imaging studies on brain slices of a mouse model of Alzheimer's disease
- Carry out electrophysiological studies on brain slices of a mouse model of Alzheimer's disease
- Use viral vectors (AAVs) to express FRET sensors in vivo
- Analyze and communicate the results produced
- Write scientific articles.

Skills

- The candidate must hold a PhD in neuroscience and have demonstrated productive research.
- Strong knowledge in the field of brain metabolism and glial cell
- Autonomy in carrying out electrophysiological studies
- Authorization to experiment on animals
- He (she) must be motivated by biomedical research, autonomous, rigorous (s) and able to work in a team.

Work Context

The neurodegenerative diseases laboratory (CNRS CEA UMR 9199) is located at MIRCen at the CEA center in Fontenay-aux-Roses. It is directed by Emmanuel Brouillet and co-directed by Gilles Bonvento and includes 80 people. The research team includes 6 researchers, technicians and PhD students and is interested in cellular interactions in neurodegenerative diseases (Alzheimer, Huntington and Parkinson).

Constraints and risks

- Work in BSL2 laboratories for the use of viral vectors
- Animal experimentation on rodents

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