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Portail > Offres > Offre UMR9199-ANSPER-003 - Postdoc (H/F) - Modélisation de la maladie de Huntington dans les neurones humains : Evaluation comparative de médicaments et d'agents de thérapie génique anti-Huntingtine

Postdoc (M/F) – Huntington's disease modeling in human iPS neurons: Comparative assessment of Huntingtin lowering drugs and gene therapy agents

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Français - Anglais

Date Limite Candidature : jeudi 4 mars 2021

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General information

Reference : UMR9199-ANSPER-003
Workplace : FONTENAY AUX ROSES
Date of publication : Thursday, February 11, 2021
Type of Contract : FTC Scientist
Contract Period : 18 months
Expected date of employment : 1 April 2021
Proportion of work : Full time
Remuneration : According to CNRS
Desired level of education : PhD
Experience required : Indifferent

Missions

Post-doctoral researcher (M/F), 18 month+ term contract to improve and use new human cellular models to model loss of HTT neuronal functions in Huntington's disease.

Activities

Our main objective is compare the impact of different source of HTT lowering drugs and gene therapy agents on selected neuronal function of HTT protein. For that we take advantage of neurons derived from human induced pluripotent stem cells from HD patient.


The project will combine a wide range of cell biology approaches with imaging analyses. The candidate will be ask to:

-Produce different types of neurons cells from human wt iPS lines (amplification, quality control, banking)
- Analyze different cell phenotypes, including the synaptic or neuronal activity of cells treated with drugs or agents.
- Analyze and communicate the results produced
- Write scientific articles.

Skills

The candidate must hold a PhD in neuroscience.

She/he must absolutely be able to demonstrate established competence in the culture and neuronal differentiation of human pluripotent stem cells. He/she will have to be motivated by biomedical research, autonomous, rigorous and able to work in a team.
He/she should also have a strong background in neurobiology, cell biology and/or central nervous system biology.

Work Context

The program is part of a long-standing effort to establish and use cellular models of neurodegenerative pathologies using human pluripotent stem cells.
The present project focuses on Huntington disease. The team that the applicant will join is co-led by Dr. Anselme Perrier. The team is part of the CEA/CNRS/Univ Paris Saclay UMR9199 unit headed by Dr Gilles Bonvento in the MIRcen department headed by Dr Philippe Hantraye at the CEA center of Fontenay-aux-Roses.

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