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Portail > Offres > Offre UMR9198-CHROUL1-034 - Chercheur sur l'impact du métabolisme de la paroi cellulaire sur la résistance aux antibiotiques et la libération des toxines chez Clostridioides difficile. H/F

Postt Doctoral position available on the role of cell wall metabolism on antibiotic resistance and toxin release in Clostridioides difficile M/F H/F

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : jeudi 12 novembre 2020

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General information

Reference : UMR9198-CHROUL1-034
Workplace : ORSAY,ORSAY
Date of publication : Thursday, October 01, 2020
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 February 2021
Proportion of work : Full time
Remuneration : Monthy gross salary between 2728€ to 3145€ according to experience
Desired level of education : PhD
Experience required : 1 to 4 years

Missions

The project aims to identify and characterize cell wall factors involved in the resistance to β-lactam antibiotics and in toxin release in the major human enteropathogen Clostridioides difficile.

Activities

Multidisciplinary approaches including bacterial genetics, targeted molecular biology, biochemistry, high-throughput sequencing techniques, fluorescence and electron microscopy and in vivo infection models will be used to complete the project.

Skills

The candidate should have a strong knowledge and expertise in the field of cell wall structure and architecture of Gram-positive bacteria.
The applicant will have recently obtained a PhD (2019 or 2020) and have strong interest and a proven track record of achievements in bacteriology, molecular biology and protein biochemistry.
The candidate is expected to have previous experience in super-resolution microscopy, fluorescent reporters for single-cell analysis, RNA-seq and/or transposon insertion sequencing (Tn-seq)
Experience with manipulation of strict anaerobic bacteria is not mandatory but would be a plus.
Good communication skills in English is required.
Candidates should show enthusiasum, self-motivation and rigor

Work Context

L'I2BC est une très grande unité mixte de recherche CNRS, CEA et Université Paris Saclay. L'institut groupe près de 700 personnes réparties entre 60 équipes de recherche et 14 plateformes technologiques de haut niveau.
Le poste à pourvoir est dans l'équipe ARN régulateurs des Clostridies qui fait partie du département de Microbiologie et qui est située sur le site d'Orsay.

Constraints and risks

The team "Regulatory RNAs in Clostridia" which belongs to the Microbiology department is located on the Paris-Saclay University campus in Orsay and is part of the Institute for Integrative Biology of the Cell (I2BC). I2BC is an institute of international visibility affiliated with the CNRS, CEA and University Paris-Saclay and consisting of nearly 60 research teams and 14 cutting-edge technology platforms and approximately 700 persons.

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