Reference : UMR9197-ODILEC2-108
Workplace : SACLAY
Date of publication : Thursday, June 16, 2022
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 October 2022
Proportion of work : Full time
Remuneration : gross monthly salary between €2700 and €3800 depending on experience (according to the CNRS salary scale)
Desired level of education : 5-year university degree
Experience required : Indifferent
The candidate will take autonomous responsibility for a comparative study of several mouse models of a neurodevelopmental pathology, will develop tools for gene therapy and for the analysis of electrophysiological signals in interaction with foreign collaborators and clinicians, and will participate in the training of interns and technical staff.
The study will be mainly based on in vivo electrophysiological approaches (ERG) complemented by intraocular injections of treatments, behavioural tests, cellular and molecular analyses by confocal microscopy, and statistics. New protocols and tools for ERG signal analysis and statistics will be developed in collaboration. The candidate will write regular reports in English on the progress of his/her work, as well as conference papers and publications.
The candidate must be proficient in in vivo electroretinographic recordings in anesthetized mice, ERG signal analysis and English (written and spoken). Certification in animal experimentation is desired. Experience or expertise in ERG and psychophysical measurements in animals and/or humans, intraocular injections in mice, and/or immunohistochemistry and confocal microscopy techniques will be appreciated, but is not mandatory as these techniques can be learned during the project.
The postdoctoral fellowship will be carried out in the "Plasticity, Cognition and Neuropathologies" team led by Cyrille Vaillend in the "Cognitive and Network Neuroscience" department (CNN) of the Paris-Saclay Institute of Neuroscience. The project is part of a funded international and multidisciplinary research program; interactions and training periods will involve other teams of the Institute, and an international collaborative network including ophthalmologists, psychophysiologists, neurophysiologists and molecular biologists in France and abroad (Germany, Hungary, Brazil). The salary will depend on the candidate's experience.
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