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Reference : UMR9012-ALEHEN-018
Workplace : ORSAY,ORSAY
Date of publication : Thursday, October 08, 2020
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 December 2020
Proportion of work : Full time
Remuneration : between 2 700 and 4 000 € gross monthly agent depending on experience
Desired level of education : 5-year university degree
Experience required : Indifferent
Nowadays, the major challenge of any oncological neurosurgery is the accurate delimitation of the tumor margins in order to achieve a maximal safe resection while preserving the adjacent healthy eloquent areas. The intra-operative identification of tumor infiltration zones is a major challenge today and requires the development of high-performance and reliable imaging tools. To address this challenge, we are developing a multimodal fibred endomicroscope, able to collect tissue autofluorescence to perform high resolution intraoperative imaging, in order to improve the surgical operation quality. This endomicroscope will include an endoscopic miniature imaging probe head that have small physical dimensions in order to be compatible with the surgical trocar used in the operating room.
The post-doctoral fellow will be part of the Multimodal Instrumentation and Tissue Imaging / IMIT team at the IJCLab. He will work under the supervision of Ms. Abi Haidar Darine in the IMOP project for the development of a multimodal miniature endomicroscope and its tissue database on the instrumental part.
The postdoctoral fellow will work on the development of a miniature imaging probe head based on a MEMS (MicroElectroMechanical System) distal scanning mirror. This imaging probe should be able to ensure confocal laser scanning in order to perform fluorescence and second harmonic generation (SHG) imaging. The technological challenge is that the system is able to fit in a biopsy trocar. This imposes to overcome many technological challenges while maintaining the performances necessary for multimodal nonlinear imaging. The probe will constitute an innovative clinical tool for performing real-time in vivo optical biopsy.
He/she will be in charge of designing the probe, performing optical simulations and choosing the optimal optical elements for a high non-linear excitation efficiency, developing the electronic drive and control software. He/she will be in charge of coupling the fabricated probe with the already developed endomicroscope and to optimize this coupling to obtain a high collection efficiency. The post will contribute in particular to different aspects:
Feasibility study and miniaturization of the probe
1. Studying the global architecture of the probe and defining the optimal optical lenses that should to be integrated in the probe configuration.
2. Defining the most suitable MEMS mirror model and actuation type.
3. Performing optical simulations on Zemax to Validate the configuration and the design feasibility.
Studying and measuring the effect of the optical probe elements on the laser pulse duration.
MEMS mirror Characterization
The characterization of the MEMS mirror and the development of the electronic drive software will be the responsibility of the postdoctoral fellow and will be carried out in several stages:
4. The development of the control electronic boards of the MEMS control and drive software and to be synchronized with the detection system of the endomicroscope. The validation tests of this software will be performed on an existing commercial scanning system (galvanometric mirrors, thorlabs).
5. Setting up a test bench for the characterization of the optical, mechanical and electronic properties of the probe (spatial resolution, field of view, scanning speed and stability, pixel dwell time, response time, frequency response, mechanical response linearity, ...).
Applicants must have a PhD in optical instrumentation or any other related field.
A research experience on a similar work justified by at least one first/co-first or second author of a publication with a related or similar subject of the project activities.
A good knowledge of nonlinear optics, as well as a demonstrated expertise in instrumentation ideally with experience in simulations (e.g. zemax).
A solid skill in Matlab programming is also essential.
A good level of spoken and written English is required.
"Laboratoire de Physique des 2 Infinis Irène Joliot-Curie” is a physics laboratory under the supervision of CNRS, the University of Paris-Saclay and the University of Paris. It is born in 2020 by merging five laboratories located in the scientific campus of Orsay : the Center for Nuclear and Material Sciences (CSNSM), the Imaging and Modeling Laboratory in Neurobiology and Cancer (IMNC), the Orsay Nuclear Physics Institute (IPNO), the Linear Accelerator Laboratory (LAL) and the Theoretical Physics Laboratory (LPT).
The laboratory's research themes are nuclear physics, high-energy physics, astroparticles and cosmology, theoretical physics, particle gas pedals and detectors as well as technical research and development and associated applications for energy, health and the environment.
This laboratory have a significant technical capabilities (approximately 280 engineers and technicians) in all the major fields required to design, develop and implement the experimental devices necessary for its scientific activity: mechanics, electronics, computer science, instrumentation, acceleration techniques and biological techniques. These technical strengths represent a major asset for the design, development and use of the necessary instruments (gas pedals and detectors). The presence of research infrastructures and technological platforms gathered on the laboratory site is also a major asset. Finally, about 90 ITAs from the administrative and support services work alongside the scientists and engineers.
Constraints and risks
- Short trips in France and abroad are to be expected.
- Exposure to radiation from class 4 lasers
- Working with chemical agents and fresh biological human samples
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