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Portail > Offres > Offre UMR9011-JEAGEN-003 - Conception, optimisation et validation d'un dispositif médical ultrasonore minimaliste porté pour la mesure du diamètre artériel. (H/F)

Design, optimization and validation of a minimalist carried ultrasonic medical device for the measurement of arterial diameter (M/F)..

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Français - Anglais

Date Limite Candidature : vendredi 4 février 2022

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General information

Reference : UMR9011-JEAGEN-003
Workplace : ORSAY
Date of publication : Friday, January 14, 2022
Type of Contract : FTC Scientist
Contract Period : 18 months
Expected date of employment : 1 March 2022
Proportion of work : Full time
Remuneration : The financial conditions are based on the CEA postdoctoral fellowships and depend on the years of experiences of the candidate. (between € 2,000 and € 2,500 gross monthly)
Desired level of education : PhD
Experience required : Indifferent

Missions

Context and objectives
The measurement of physiological parameters is essential for diagnosing a chronic disease or monitoring its progress in response to treatment. Evaluating these parameters in everyday life is a technological challenge for personalized medicine. In recent years, the carried devices have multiplied, whether for medical purposes or for well-being. They are efficient in terms of ergonomics and autonomy, but the disappointing robustness of the measure remains problematic from a medical point of view.
For several years, the LETI / DTBS / LS2P team has been developing systems for measuring physiological parameters worn on the person, based on different modalities (optical, electrical, accelerometer, etc.). The approach taken by the DIAMAND project is to combine these different modalities with an ultrasound measurement of physiological parameters, and in particular the diameter of the artery. The objective is to propose and test a minimalist architecture and acquisition strategy to obtain ultrasonic artery diameter measurements with high precision (qqs µm). This "minimalist" aspect will make it possible to limit the overall size of the device, its energy consumption, and the amount of data generated, so as to be able to subsequently integrate this measurement into a multimodal device for measuring physiological parameters.

Activities

Program
The first phase of the project will consist in optimizing, by simulation, the parameters of the probe and the associated acquisition protocol, considering a simple configuration (canonical geometries, absence of noise, perfect interfaces, etc.). This optimization will be carried out with CIVA simulation tools, including the generation and reception of waves by any sensor, its propagation within heterogeneous and / or anisotropic media, its diffraction by structure or defects. The “ray” type propagation model considers: i / refraction and reflection phenomena, with and without mode conversion at the various interfaces, II / phased array probes and the various associated acquisition and imaging modes, III / all the frequency complexity of the transmission signal because the calculation is carried out in impulse response. A processing algorithm will also have to be developed to extract, from the simulated measurements, the diameter of the artery. The constraints imposed will concern in particular the overall size of the device, its consumption, and the quantity of data generated and to be processed. The expected performance will be expressed in terms of accepted measurement error and frequency of repeated measurements. The parameters expected for this first dimensioning will be the number of elements, their arrangement, the central and sampling frequencies of the signals used as well as the acquisition mode (transmission / reception combined or separated, with or without focusing, with the all of the elements or not…). Upon completion, specifications will be drawn up for the manufacture of a first prototype with piezoelectric technology.

The second phase will be dedicated to a sensitivity study of the performance of this design. We will thus define a certain number of uncertain parameters, for example the speed of propagation in the blood, a possible deformation of the artery, an error of positioning of the probe, the presence of a noise related to the complexity of the crossed tissues or the noise generated by the components, as well as an associated variation range, to generate a simulated database. Using metamodel technology and statistical analysis tools available in CIVA, various sensitivity studies will then be carried out in order to estimate the influence of the various parameters and their consequences on the performance of measurements, in particular the error made.

The third phase will be dedicated to the experimental validation of the piezoelectric probe prototype made from the specifications. The first acquisitions will be carried out in vitro on phantoms whose geometric and ultrasonic parameters, in particular the propagation speeds, will be perfectly controlled. The objective will be in particular to establish the electrical powers necessary in order to obtain a satisfactory signal-to-noise ratio and to estimate the nominal precision of measurement of the diameter of the artery. Finally, a sensitivity study will be carried out under conditions comparable to that carried out during the simulation study, in order to confirm the conclusions in terms of performance evolution of the measurement of the diameter of the artery. A second campaign will be carried out in vivo. Measurements of the diameter of a human artery made with this prototype will be compared with those made with ultra-fast ultrasound scanners available at BIOMAPS.

Finally, an in vivo validation campaign will be carried out with a PMUT or CMUT sensor, existing or specifically produced within the framework of the project, the dimensions of which may have been adapted according to the results of previous studies. The objective will be to ensure that this minimalist system achieves the expected performance under realistic conditions.

Skills

Profile
This post-doc will be carried out in the Paris region, on the Saclay plateau. It has two main stages, the first carried out within the LIST / DISC team, will use simulations using an existing and easily accessible platform. The second, carried out in the BIOMAPS laboratory, at the Frédéric Joliot d'Orsay Hospital Service, will be dedicated to experimental validations in vitro and in vivo using the available experimental means. The candidate, holder of a doctorate, should have solid skills in ultrasound measurement or imaging, preferably in the health field. Knowledge of modeling and simulation would be a plus.

Work Context

Locations
The DISC, the Imaging and Simulation Department for LIST Control, has, through the development of the CIVA non-destructive testing expertise platform, recognized experience in the simulation of the propagation of ultrasonic waves in complex structures, relying in particular on experimental validations and benchmarking studies. He also has strong skills in the development of advanced imaging tools, in particular adaptive, using multi-element probes and the design of innovative probes.
The Paris Saclay Multimodal Biomedical Imaging Laboratory (BioMaps) aims to design biomedical imaging methods, instruments and agents for different imaging modalities and their transfer to clinical applications in neurology and oncology. BioMaps is a major player in medical imaging research at the Physics-Chemistry-Medicine interfaces of Paris-Saclay. This unit brings together the expertise and equipment essential for the development of innovative approaches in imaging and their application for the study of physiopathological processes, for diagnosis and therapeutic evaluation. BioMaps is located at the Service Hospitalier Frédéric Joliot, in the heart of the Orsay hospital. Its location allows a direct link between research teams, patients and doctors.

Constraints and risks

Without

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