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Portail > Offres > Offre UMR8612-SIMMUR-012 - Chercheur Post Doctoral_ Microfluidique/Modelés cellulaires 3D/microenvironnement (H/F)

Postdoctoral researcher position in Microfluidic/3D tumor and microenvironment engineering (H/F)

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : vendredi 26 août 2022

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General information

Reference : UMR8612-SIMMUR-012
Workplace : CHATENAY MALABRY
Date of publication : Friday, August 5, 2022
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 November 2022
Proportion of work : Full time
Remuneration : between 2500 and 3500 € gross monthly
Desired level of education : PhD
Experience required : 1 to 4 years

Missions

The preclinical development of cancer therapies generally involves the evaluation of potential anticancer agents on tumor cell cultures in vitro. The poor performance in terms of predicting therapeutic responses in humans from available in vivo or in vitro models has motivated the search for alternative in vitro models that are truly predictive of human cancer. A recent approach to in vitro cancer modeling is based on the development of organs on microfluidic chips associated with the culture of spheroids allowing to recapitulate the multicellular architecture, the tissue-tissue interfaces, and the physiologically relevant physical microenvironment of cancers in the human body. man. In this context, the TumFlu project funded by the LABEX LaSIPS proposes to manufacture and optimize a dedicated microfluidic device then to undertake the culture of tumor spheroids in the microfluidic system and finally to study the role of the tumor microenvironment (stiffness, oxygenation) on the proliferation and cell migration and response to treatments.

Activities

• Design and fabrication of a microfluidic device
• Construction of a 3D tumor model
• Optimization and validation of cell culture in the microfluidic device
• Understand how environmental conditions (i.e., biochemical, and mechanical clues) will affect tumor progression and metastatic capacity.
Analysis of results and preparation of progress reports.

Skills

Proficiency in cell biology, bioassays, confocal imaging is a requirement.
Knowledge of 3D culture methodologies, and/or tumor-microenvironment interactions is also an asset.
Highly desirable skills in micro-engineering and microfluidics (photolithography, microfluidic device fabrication processes, flow control in biochips, etc.)

Work Context

The postdoctoral internship will take place mainly within the CNRS C2N laboratories (Centre for Nanosciences and Nanotechnologies) and the Institut Galien Paris-Saclay of Paris-Saclay University in close collaboration with the CNRS LMPS laboratory (Laboratory of Mechanics Paris-Saclay), CentraleSupélec, Paris-Saclay University within the framework of the LABEX LaSIPS TumFlu project.

Constraints and risks

Not any specific risk

Additional Information

The eligible candidate must be within 2 years of his/her PhD thesis defense or in position to obtain a PhD in the near future. --
We are looking for a motivated full-time post doc who will work on the construction of a biomimetic device able to reproduce in vitro the physio-pathological conditions of tumors in vivo by opportune combination of 3D cell culture conditions and microfluidic technology.
The candidate must hold a PhD in biology, microtechnology or tissue engineering. To carry out this interdisciplinary project the candidate should possess solid skills in the areas of cell biology, biological assays and/or tumor-microenvironment interactions. Validated experience in microengineering and microfluidics (e.g., photolithography and microfluidic fabrication processes, flow control in biochip, etc…) is highly desirable.
The candidate must be proficient in oral and written English. We are looking for candidates interested to work in a multidisciplinary research environment, who have excellent communication skills, are team-oriented, focused, self-motivated, trustworthy, critical, and open-minded.

We exclusively accept applications submitted through our online application portal. Applications via email will not be considered.

The application must be in English and include a curriculum vitae with names and contact information of 3 referees, a complete list of publications and a statement of research interest. The application documents must be sent as a single PDF file. Incomplete applications will not be considered for evaluation.
Applications will be reviewed as they are received until the position is filled.

For enquires about the position, please email Dr Bertrand David (bertrand.david@centralesupelec.fr), Dr Anne-Marie Haghiri (anne-marie.haghiri@c2n.upsaclay.fr) or Dr Simona Mura (simona.mura@universite-paris-saclay.fr). with the subject “LabexLaSIPS_postdoc”.

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