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Portail > Offres > Offre UMR8261-GREBOE-003 - Position postdoctoral de 3 ans (H/F): Nouveaux mécanismes de résistance aux antibiotiques

3-years postdoctoral position (M/W): New mechanisms of antibiotic Resistance

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Français - Anglais

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General information

Reference : UMR8261-GREBOE-003
Workplace : PARIS 05
Date of publication : Friday, February 01, 2019
Type of Contract : FTC Scientist
Contract Period : 36 months
Expected date of employment : 15 March 2019
Proportion of work : Full time
Remuneration : Gross salary between 3000 et 3600 Euro according to the experience
Desired level of education : 5-year university degree
Experience required : Indifferent

Missions

A three year postdoctoral position (1 year renewable) starting early of 2019 is open in the research group of Grégory Boël at the “Institut de Biologie Physico-Chimique” (IBPC), in the unit "Expression Génétique Microbienne" (CNRS UMR 8261) and the group of Yaser Hashem at the Université de Bordeaux.

Activities

We have recently shown that protein belonging to the ABC-F family are translation facteur that modulate ribosome activity (Boël, G., et al., / Chen, B., et al., Nat Struct Mol Biol, 2014. 21(2)). Some ABC-F proteins are involved in bacterial adaption to their environment, but some specific ABC-F proteins are also involved in antibiotic resistance. Recent publications confirmed that the antibiotic resistance is mediated by direct interaction of the ABC-F factor and the ribosome (Crowe-McAuliffe C, et al., Murina V, et al.) but the mechanism of action is still not understood. We propose to study this question using a genetic, biochemical and structural approach. Ours groups have developed an experimental setup that allows easy study of one ABC-F in vivo and in vitro.

Boël G., et al. Nat. Struct. Mol. Bio. 21:143-151 (2014)
Chen B., . Nat. Struct. Mol. Bio.,21:152-159 (2014)
Crowe-McAuliffe C, et al. Proc Natl Acad Sci U S A. 115(36):8978-8983 (2018)
Murina V, et al. Nucleic Acids Res. 46(7):3753-3763. (2018)

Skills

-We are seeking a highly motivated candidate with a PhD in any area of bacterial molecular biology and biochemistry. The ideal candidate should be familiar with protein synthesis and RNA biochemistry and structural biology. Previous experience with cryo- electron microscopy is a plus. The successful candidate should be a motivated scientist with great potential and a good team-worker.

Applicants should send their CV with full list of publications and three references that can be contacted, to Grégory Boël at boel@ibpc.fr and Yaser Hashem yaser.hashem@u-bordeaux.fr.

Work Context

Most of the experimental work will be carried out by the candidate at the IBPC in the group of G. Boël and the cryoEM reconstruction of the samples produced will be determined in the group of Yaser Hashem.

The IBPC is a multidisciplinary institute of the Centre National de la Recherche Scientifique (CNRS) located in the center of Paris on the Curie Institut campus.

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