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Reference : UMR8199-HELDEG0-018
Workplace : LILLE,LILLE
Date of publication : Friday, October 09, 2020
Type of Contract : FTC Scientist
Contract Period : 36 months
Expected date of employment : 1 January 2021
Proportion of work : Full time
Remuneration : Between 2675 et 3805 euros brut per month
Desired level of education : 5-year university degree
Experience required : 1 to 4 years
A post-doctoral position is available at the European Genomic Institute for Diabetes (UMR 8199 CNRS, INSERM, Institut Pasteur de Lille, CHU Lille, Université de Lille) in the “Microbiome and Metabolome in Cardiometabolism” group supervised by Prof. Marc-Emmanuel Dumas, in Lille, France.
The successful candidate will be responsible for studying the role of the microbiome and microbial metabolites in cardiometabolism using cellular and animal models, backed by the team's expertise in metabolomics and metagenomics. He/She will contribute to a deeper understanding of microbiome-host molecular metabolic and signalling crosstalk.
The project will focus on developing preclinical assays in animal models, cell-based assays, organs-on-a-chip in the context of cardiometabolic diseases (obesity, insulin resistance, type 2 diabetes, non-alcoholic fatty liver disease, ischaemic heart disease) with a range of functional “omics”, including metabolomics and metagenomics.
The post holder will oversee the experimental dissection of the microbiome-host metabolic and signalling crosstalk. More specifically, the post holder will be responsible for:
• development and implementation of experimental cell-based assays and animal model protocols
•development of faecal microbiota transplantations and other strategies to modulate the microbiome
• testing the biological activity of microbial metabolites and identifying their signalling targets
• target gene validations in cells and animal models
He/She will be responsible for data processing and scientific dissemination of results (drafting of scientific articles in English and participation in conferences). The successful candidate will play a role in influencing the project: design of workflow, optimisation and benchmarking, prioritisation of projects, interpretation of results.
The candidate will:
• hold PhD in Physiology, Cell Biology, Biochemistry, Microbiology, Life science engineering or similar
• be an expert in animal experimentation and cell culture
• be an expert in signal transduction and/or kinase biology
• have experience in the microbial-host metabolic and signalling crosstalk
• have knowledge of microbial and host metabolism
• have knowledge of inter-organ crosstalk
• have knowledge of biostatistics
• master the English language (written and spoken)
• have an interest in multidisciplinary work
• demonstrate autonomy, rigor, critical thinking, problem solving and ability to work within an international team
The researcher will join the “Microbial Metabolome in Cardiometabolic diseases” team at EGID (recognised by a 'Laboratory of Excellence' award), whose research objectives are to study the microbiome and its metabolic output to identify microbial metabolites and lipids associated with cardiometabolism and study the bioactivities of the microbial metabolome in cardiometabolic processes. The Institute provides an excellent intellectual environment and most of the infrastructure required to carry out the project, with direct access to state-of-the-art platforms including high-throughput sequencing (LIGAN-PM, 'Equipment of Excellence' platform award), animal facilities with a small imaging platform and a core facility for metabolic studies (metabolic cages, treadmill, CTscan, PET scan, MRI), cell imaging facility (confocal microscopy, electron microscopy), flow (INFLUX BD) and mass (CyTOF) cytometry. More specifically, the candidate will be part of the 'Accueil Talent International' project awarded to Prof. Dumas and funded by ISite, Région Hauts-de-France and Métropole Européenne de Lille. The project integrates expertise in analytical chemistry, chemometrics, metagenomics and validations in cellular and animal models to identify metabolic pathways disrupted in cardiometabolism. The researcher will strongly interact with colleagues within the group, the Institute and international collaborators.
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