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Portal > Offres > Offre UMR8003-DANZYT0-001 - Chercheur Post-doctorant (H/F) sur les mécanismes de dégénérescence des motoneurones dans la SLA

Post-doctoral researcher (M/F) on the mechanisms of motor neuron degeneration in ALS

This offer is available in the following languages:
Français - Anglais

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General information

Reference : UMR8003-DANZYT0-001
Workplace : PARIS 06
Date of publication : Thursday, May 02, 2019
Type of Contract : FTC Scientist
Contract Period : 18 months
Expected date of employment : 1 July 2019
Proportion of work : Full time
Remuneration : about 2700 € to 3100 € (gross salary) depending on the experience.
Desired level of education : PhD
Experience required : 1 to 4 years

Missions

The post-doc will take part to a research program that aims at investigating the role of synaptic connectivity on the degeneration of spinal motor neurons in Amyotrophic Lateral Sclerosis (ALS). This issue will be tackled on mouse models of ALS by combining chemogenetics interventions using new viral vectors and cutting-edge in vivo electrophysiological methods for intracellular recordings of spinal motor neurons.

Activities

In vivo electrophysiological experiments on anesthetized mice
Surgery on mice
Intraspinal, systemic or intramuscular injections of AAVs (level 1 confinement)
Data analysis and interpretation
Bibliographical reading
Article writing
Communications to conferences

Skills

-Strong expertise in electrophysiology
-Good knowledge in molecular and cell biology would be appreciated
- Legal training for animal experimentation (conceptor level). In case the applicant has not been trained, she/he will have to follow the mandatory training as soon as possible after hiring.
-Team player
-Autonomous
-Good manual dexterity
-Effective verbal and written communication
-Fluent in english

Work Context

The research will be performed in the framework of a project funded by the Radala Foundation for ALS research. The project involves two permanent researchers and one engineer who will train the post-doc in all the conceptual and methodological aspects of the project. The research group belongs to the team "Motor Neurons and Neuromuscular Junctions" of the SPPIN research unit at the Paris Descartes University. The project will be conducted in collaboration with one molecular biologist at the University of Ulm in Germany.

Constraints and risks

The in vivo electrophysiological experiments may last up to 7-8 hours during which we need to stay very focused. They require a great manual dexterity.

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