Reference : UMR7325-VALSEV-070
Workplace : MARSEILLE 09
Date of publication : Monday, September 19, 2022
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 November 2022
Proportion of work : Full time
Remuneration : Between 2889 € and 4082 € gross per month depending on experience
Desired level of education : PhD
Experience required : 1 to 4 years
Dendrimer nanosystems for nucleic acid delivery
The candidate will construct, characterize and evaluate different dendrimer nanosystems for the delivery of nucleic acid therapeutics for immunotherapy against glioblastoma. This project is within a collaborative and interdisciplinary research consortium under the frame of H2020 Era-Net EuroNanoMed project “iNanoGUN”.
Motivated candidates with team-work spirit and background in nucleic acid delivery are welcome to apply.
Please submit online a single PDF file with detailed CV including education and work experience, summary of PhD thesis (1 page maximum) and post-doc research (1 page maximum) and at least tworeference letters of the supervisors.
Design, characterisation and evaluation of dendrimeric nanosystems for immunotherapy
The candidate will design, synthesize, characterize and evaluate different functional dendrimer nanosystems for the delivery of nucleic acid therapeutics in immunotherapy against the glioblastoma. The size, morphology, stability and capacity of these dendrimer nanosystems to transport nucleic acid will be studied using DLS, TEM, HPLC and fluorescent spectroscopy. Their delivery efficacy will be evaluated in vitro using cell-based experiment and in vivo using animal models. Also a structure-activity relationship study will be released to optimize the dendrimer nanosystems for nucleic acid delivery.
- Formulation, characterization and evaluation of dendrimer nanosystems for biomedical applications
- Nucleic acid delivery and functional assay
- Anticancer activity assay in vitro cell experiments et in vivo animal experiments
- Good communication and writing skill in English
As a joint research institute of CNRS and Aix-Marseille University, CINaM is composed of about 150 people and 5 departments and is located on the Luminy Campus in Marseille (France).
The recruited person will work in the group of Dr. Ling PENG in the Department of Molecular Engineering and Functional Materials (IMMF). This department is made up of 21 researchers and teacher-researchers, mainly chemists. English speaking is mandatory.
Constraints and risks
Hygiene and Safety requirement related to the handling of chemical and biochemical products. The chemical and biological experiments will be carried out in the equipped and functional laboratory.
We talk about it on Twitter!