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Reference : UMR7281-AURBIM-005
Workplace : MARSEILLE 09
Date of publication : Monday, November 22, 2021
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 January 2022
Proportion of work : Full time
Remuneration : 2743 et 3896 euros bruts mensuels
Desired level of education : PhD
Experience required : Indifferent
Characterization of the structural flexibility of disordered regions contained in proteins involved in a process of DNA repair by site-directed spin labeling EPR spectroscopy
Applicants are required to submit their detailed CV online, enclosing two letters of reference from the main supervisors in a single pdf document.
- Site-directed spin labeling (nitroxide radicals) on proteins
- Label dynamics analyses by EPR spectroscopy
- Inter-label distance measurements by pulsed EPR
- Complementary biophysical techniques
- Functional assays
- Oral presentations (team meetings, laboratory seminars, conferences)
- Writing reports / publications
- Skills in EPR spectroscopy in continuous and pulsed mode
- Spin labeling of proteins will be appreciated
- Other spectroscopies for protein characterization will be appreciated (UV/vis absorption, circular dichroism …)
- Fluent knowledge of English
- Team spirit
The “Bioénergétique et d'Ingénierie des Protéines » (BIP) laboratory is a Joint Research Unit (UMR) co-supervised by AMU/CNRS. It is located on the Joseph Aiguier campus and is part of the “Institut de Microbiologie de la Méditerranée” (IMM). The BIP lab currently includes about 70 people: 20 researchers and 12 assistant and full professors, 9 engineers and technicians, including 1 university engineer, 8 post-docs and 20 PhD students.
The recruited person will work under the responsibility of Pr. Valérie BELLE (BIP) and in collaboration with Pascale Barbier (Institut de Neurophysiopathologie, Marseille) for the functional assays and further biophysical characterizations.
Constraints and risks
The constraints are those related to hygiene and safety necessary for the handling of chemicals and specific cryogenic equipment dedicated to EPR spectroscopy.
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