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Portail > Offres > Offre UMR7277-STENOS0-003 - Chercheur/se postdoctoral (H/F) – Maintien de l'homochiralité du protéome

Postdoctoral researcher (M / F) - Maintainance of the proteome homochirality

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : mardi 20 avril 2021

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General information

Reference : UMR7277-STENOS0-003
Workplace : NICE
Date of publication : Tuesday, March 30, 2021
Type of Contract : FTC Scientist
Contract Period : 9 months
Expected date of employment : 14 June 2021
Proportion of work : Full time
Remuneration : Between 2800 € -3900 € gross monthly according to experience
Desired level of education : PhD
Experience required : 5 to 10 years

Missions

The objective of the project is to characterize the mechanisms involved in the maintenance of homochirality in vivo using the Drosophila model. The candidate will have to develop new tools for analyzing homochirality in vivo.

Activities

A 9-month Post-Doc scholarship is available in Stéphane NOSELLI's group at the Institut de Biologie Valrose (iBV) of the Université Côte d'Azur in Nice, FR (ibv.unice.fr/research-équipe/ noselli /).
The laboratory studies the origin and functions of biological chirality. Homochirality is one of the key principles of life. Our proteins are made up of homochiral monomers, exclusively L amino acids, while D amino acids are considered non-proteinogenic. This is crucial, because enzymes have stereoselective binding modes. Recent advances demonstrate that various conditions (especially stress) can lead to the spontaneous emergence of D-AA in our proteins and to the loss of the enantiopurity of the proteome. The objective of the project is to characterize the mechanisms involved in the maintenance of homochirality in vivo using the Drosophila model.

Applicants with a background in developmental biology, cell biology, and biochemistry are encouraged to apply. Interested candidates can contact Stéphane Noselli (noselli@unice.fr).

The Institut de Biologie Valrose (27 teams; 300 people; 25 nationalities) is an international institute (English is the working language) with a very rich scientific environment. The iBV provides cutting-edge technological infrastructure and platforms, with a collaborative and lively atmosphere in a very attractive city / region. (ibv.unice.fr)

Selected publications :

Speder et al., Nature 2006
Gettings et al., PLoS Biology 2010
Suzanne et al., Cur Biol 2010
Petzoldt et al., Développement 2012
Coutelis et al., Dev Cell 2013
Géminard et al., Genesis 2014
Coutelis et al., EMBO Reports 2014
Gonzales-Morales et al., Dev Cell 2015
VandeBor et al., Cell Reports 2015
Rousset et al., PLoS Genetics 2017
Roumengous et al., Cell Reports 2017
Juan et al., Nat. Com. 2018
Tingler et al., Cur. Biol. 2018
Lebreton et al., Science 2018
Chougule A et al., PLoS Genet. 2020

Skills

Developmental biology
Cellular biology
Biochemistry
Genetic
At least 3 years of experience with the Drosophila model is required
Written and oral expression in English
Microscopy experience (confocal imaging)
Experiment with the circular dichroism spectroscopic technique

Work Context

The Institut de Biologie Valrose (27 teams; 300 people; 25 nationalities) is an international institute (English is the working language) with a very rich scientific environment. The iBV provides cutting-edge technological infrastructure and platforms, with a collaborative and lively atmosphere in a very attractive city / region. (ibv.unice.fr)

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