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Reference : UMR7057-CARPHI-005
Workplace : PARIS 06
Date of publication : Friday, July 24, 2020
Type of Contract : FTC Technical / Administrative
Contract Period : 12 months
Expected date of employment : 1 October 2020
Proportion of work : Full time
Remuneration : Salary between 2510 et 2694 euros gross montly
Desired level of education : Higher than 5-year university degree
Experience required : Over 10 years
Extracellular vesicles (EVs), especially from mesenchymal stem cells (MSCs) are currently reported to play a direct role in restoring tissue function and homeostasis. MSC EVs have been increasingly regarded as competent effectors in alternative to cells for regenerative medicine in a paradigm shift switching cell therapy to sub-cellular (EV) therapy. One important challenge in the implementation and scale-up of MSC EV production is protocol transfer/implementation into bioreactors compatible with good manufacturing test (GMP). We intend to set-up MSC culture in scalable stirred tank GMP bioreactors in order to produce EVs.
We intend to set-up MSC culture in scalable stirred tank GMP bioreactors in order to produce EVs. Besides, we will develop a formulation based on the obtained vesicles combined to a hydrogel and test its immune-modulatory effect in vitro and in vivo.
Applicant expertise: cell culture in bioreactors, cell culture of mammalian cells in stirring tank bioreactors using microcarriers, extracellular vesicle production and characterization, immune-modulatory tests in vitro and in vivo.
The recruit will benefit from an internationally renowned interdisciplinary environment at the MSC laboratory, recognized for their expertise in the field of biophysics.
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