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Reference : UMR7042-FRACOL-002
Workplace : STRASBOURG
Date of publication : Tuesday, November 12, 2019
Type of Contract : FTC Technical / Administrative
Contract Period : 12 months
Expected date of employment : 6 January 2020
Proportion of work : Full time
Remuneration : from 2643,22 euros gross monthly according to experience
Desired level of education : PhD
Experience required : Indifferent
The work is part of a premature program of a research project that recently led to the filing of a patent. Asymmetric catalysis is an ideal methodology for the pharmaceutical industry to produce biologically active compounds, high value-added products, quickly, efficiently and respecting the principles of green chemistry. The aim is to test a new family of chiral terphenyl ligands with double axial chirality (whose original skeleton has been patented, published in Angewandte Chemie and highlighted in Nature) in asymmetric hydrogenation reac of imines or olefines to obtain enantiopure amino or amino acids of interest in the pharmaceutical industry. On the basis of the results obtained, these will be presented to companies who have shown a strong interest in this work.
Synthesize one to two families of ligands included in the patent, in particular diphosphine ligands.
- Identify asymmetric hydrogenation reactions of interest for companies and test the new ligands (potential target: the asymmetric hydrogenation of imines and olefins, a transformation that presents today a major synthetic challenge leading to the formation of chiral amines, chiral amino acids especially the unnatural, key structures in medicinal chemistry)
- Perform the first catalytic tests to evaluate the performance of the new metal complexes in the previously chosen reactions. If possible, for reactions giving promising preliminary results, the ligand design will be refined in order to find the most efficient structures in terms of reactivity and selectivity (modification of the ligand structure by introduction of substituents modifying their electronic properties and / or or steric).
Optimization of the synthesis of the selected ligand on a larger scale and optimization of the targeted reaction for future industrial application.
The candidate must have a PhD in Synthetic Organic Chemistry and have good written and oral communication skills. An experience in organometallic catalysis and asymmetric hydrogenation would be appreciated but not essential.
The work will take place in the Syncat team (www.syncat.org) at the University of Strasbourg / School of Chemistry, Polymers and Materials, UMR 7042 LIMA. The team is equipped with the necessary equipment for this project: NMR 400 MHz and 500MHZ with cryogenic probe, chiral HPLC, GC-MS, ATR-IR and classical laboratory equipment dedicated to organic synthesis. A multi-reactor for the screening of asymmetric hydrogenation reactions is also present.
The work is part of a premature project funded by CNRS
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