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Reference : UMR6230-JONFAR-002
Workplace : NANTES
Date of publication : Thursday, December 20, 2018
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 18 March 2019
Proportion of work : Full time
Remuneration : 2000-2500€ net month salary depending on experience
Desired level of education : PhD
Experience required : 1 to 4 years
The monitoring of chemical reaction in real time is a main challenge in chemistry. Detect molecular changes along the time in a complex mixture, access the conversion rate of a chemical transformation and access its kinetic allow a better understanding of mechanisms and thus to optimize reactional conditions for better conversions and selectivities. In this field Nuclear Magnetic Resonance (NMR) is one of the most powerful analytical tool for a fine structural and quantitative analysis for detecting side products and unstable products. Recently, a new generation of benchtop NMR spectrometers (<100MHz) appeared on the market. These instruments are transportable, low costs and directly linkable to a reactor unlike high field NMR. However, the real time monitoring by 1D 1H NMR of complex mixture evolving in the time remains difficult due to the low sensitivity of such compact instrument and to signal overlap at low field.
Under these conditions, the main goal of the CNRS funded project is to:
1)Develop and implement new techniques to overcome limitations of low –field NMR
2)Investigate reactional mixtures with the help of such analytical tools
To reach the main objective of the project, the postdoc will be in charge of the whole NMR methodological development to:
- Face reduced spectral resolution at low field through the development of ultra-resolved “pure shift” (PS) techniques 
- Improve the sensitivity / reduce the experimental time with fast repetition methods 
- Integrate advanced techniques and a benchtop NMR spectrometer to an autonomous flow reactor with artificial intelligence  for better understanding reactional mechanisms.
 J. Farjon, C. Milande, E. Martineau, S. Akoka, P. Giraudeau, Anal Chem. 2018, 90, 1845-1851.
 J. Farjon, Magn. Reson. Chem. 2017, 10, 883-892.
 D. Cortés-Borda, E. Wimmer, B. Gouilleux, E. Barré, N. Oger, L. Goulamaly, L. Peault, B. Charrier, C. Truchet, P. Giraudeau, M. Rodriguez-Zubiri, E. Le Grognec, F.-X. Felpin , J. Org. Chem., 2018 in press, doi: 10.1021/acs.joc.8b01821
The postdoctorate will be in charge of the whole NMR developments at low field. Candidates shall have a Ph. D. in (Bio)Chemical analysis or Chemical Physics and have demonstrated a solid track record in NMR. She/he should be open-minded due to the interdisciplinary and collaborative aspects of the project. She/he will present her/his work in national and international conferences and good skills in English are required. She/he will be highly encouraged to participate in academic (publications, conferences) and non-academic valorization (dissemination). This recruitment will provide a unique opportunity for a motivated researcher to be invested in innovative NMR developments at the interface between spectroscopy, analytical chemistry, and chemical synthesis.
The EBSI team of the CEISAM lab is recognized for developing techniques in solution-state and for applying such tools to the analysis of complex mixtures. CEISAM is equipped with NMR spectrometers ranging from 43 to 700 MHz. The EBSI team has an international recognition in NMR methodology and has recently published an ensemble of NMR tools at low field with numerous application perspectives. The project is a long term partnership with CORAIL team (CEISAM) that has a great expertise in flow chemistry and has a unique in France autonomous reactor having artificial intelligence applied in the field of catalysis.
The lab is located in the vibrant city of Nantes, close to the Atlantic coast of South Brittany.
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