Reference : UMR5635-MIKBEC-007
Workplace : MONTPELLIER
Date of publication : Friday, May 6, 2022
Type of Contract : FTC Technical / Administrative
Contract Period : 7 months
Expected date of employment : 1 July 2022
Proportion of work : Full time
Remuneration : 2130 € per month
Desired level of education : 5-year university degree
Experience required : Indifferent
For several years, the use of bone filling materials has appeared as a real alternative to autograft by orthopedic surgeons. In a context where surgical procedures are increasingly oriented towards minimally invasive and ambulatory acts, the development of bioresorbable cements is becoming a major challenge for manufacturers in this very strong growth sector. As such, in 2017, worldwide, more than one million patients suffered from vertebral compression fractures caused by metastatic tumors (Global Data Study 2005-2020). This type of indication specific to minimally invasive spine surgery remains out of reach for resorbable biomaterials. The development of a matrix from the family of apatitic cements, with optimized biological and mechanical powers, would provide a "best in class" therapeutic solution for orthopedic surgeons and interventional radiologists. The objective is the treatment of vertebral fractures and the prevention of possible local recurrences thanks to the controlled release of an active principle/drug adapted to the targeted pathology. This innovative project aims to develop and characterize new biomimetic biodegradable cements for the treatment of fractures of long bones and vertebrae, allowing both bone regeneration and the treatment of metastatic cancer disease.
The recruited candidate will be responsible for carrying out scientific experiments as part of an applied research project on the characterization of biomaterials for the treatment of bone metastases in collaboration with the IRCM. This will involve carrying out cell biology experiments; carrying out molecular biology experiments, carrying out manipulations on animals and participating in the maintenance of the laboratory.
The candidate should have general knowledge of biology. We are looking for a highly motivated candidate with experience in the implementation of different cell culture, molecular biology and animal manipulation techniques. Skills in image analysis are welcome. Interpersonal skills, dynamism, rigor and teamwork will be appreciated. The candidate must be fluent in English. In addition, well-written English will be highly appreciated.
The candidate will be located between two laboratories attached to the University of Montpellier, one with expertise in materials chemistry (the European Membrane Institute (IEM)) and the other in cancer biology (Research institute in Cancerology of Montpellier (IRCM)).
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