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Reference : UMR5502-SYLLOR-002
Workplace : TOULOUSE
Date of publication : Wednesday, January 09, 2019
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 19 February 2019
Proportion of work : Full time
Remuneration : Gross salary between 2530 et 3500€ (monthly) depending on previous experience (paid leave and social security included).
Desired level of education : PhD
Experience required : Indifferent
Building on the results of ERC BrainMicroFlow (see "Work Context" below), we now wish to broaden our fundamental understanding of brain biomechanics by studying the interactions between the microvascular system, the cerebrospinal fluid, the brain tissue and the forcing induced by the pulsatility of the macro-vascular flow. Such an understanding requires the development of fundamental models taking into account the detail of the architecture of the vascular microstructure as well as the poroelastic properties of neighboring tissues, in a formalism compatible with simulations at the macroscopic scale.
We wish to set up a structure fluid interaction model for the study of the couplings between the microvascular system, the cerebrospinal fluid and the brain tissue. The modeling scale will be of the order of one cubic millimeter. The choice of this scale makes it possible to explicitly represent the complexity of the microvascular network by a uni-dimensional network approach, and to couple this description with a poroelastic finite-element model of the brain tissue. At first, the system will be studied under static solicitations. In a second step, we want to introduce the blood pulsatility to study the reorganizations of the flows of intracranial fluids and the associated variations of the induced tissue stresses. This type of model will make it possible to interpret the macroscopic correlations obtained between biomechanical and biological clinical variables to get a fine understanding of the role of cerebral biomechanics in the development of neurodegenerative diseases.
- PhD in mechanics or fundamental physics,
- Good knowledge of numerical methods for mechanics,
- Experience required in research at the interface with the life sciences,
- Desired experience of interaction with clinical research,
- Excellent English writing skills,
- Communication skills, team spirit.
IMFT's Porous and Biological Media group has pursued a research strategy over the last fifteen years, built up on the porous media point of view to approach biomechanics from a new angle. The group's fundamental contributions to the modeling of fracture networks, double media and complex flows in reactive porous media have made it possible to develop an expertise at the highest international level in the field of biological porous media in close collaboration with the teams of the CHU Purpan in Toulouse, with significant advances. In particular, work on brain microcirculation has been recognized by the European Research Council (Consolidator Grant BrainMicroFlow, PI S. Lorthois - 2014-2019, Proof Of Concept Grant ViTAE, PI S. Lorthois - 2019-2020).
Supervision: Sylvie Lorthois (DR CNRS) in collaboration with Pauline Assemat (CR CNRS) and Eric Schmitt (CHU Toulouse).
This position is part of the ERC Consolidator project BrainMicroFlow (2014-2019).
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