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Reference : UMR5089-CHRCHA-002
Workplace : TOULOUSE
Date of publication : Thursday, January 27, 2022
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 April 2022
Proportion of work : Full time
Remuneration : Between 2663 and 3069 € gross per month depending on experience
Desired level of education : 5-year university degree
Experience required : 1 to 4 years
A post-doctoral position is available in the team of Christophe Guilhot at the Institute of Pharmacology and Structural Biology (IPBS, CNRS UMR 5089, Toulouse, France). The overall scientific objective of the team is to gain knowledge on mycobacteria and mycobacterial infections, notably tuberculosis. Mycobacteria are surrounded by an unusually thick lipid-rich cell envelope containing very long-chain fatty acids, which interact with a variety of surface-exposed lipids to form an atypical outer membrane. The mechanisms governing the transport of these lipids from the cytoplasmic compartment, where they are synthesized, to the cell envelope remain poorly understood. The selected candidate will work in the framework of an ANR-funded project (MYCOLT) aiming at deciphering the composition and organization of the molecular machinery involved in lipid transport. In close collaboration with the research teams involved in this project, he/she will identify new transport proteins and characterize in depth their topological organization, subcellular localization, and function.
The main functions of the successful candidate will be to:
- Design and implement experiments in the frame of the MYCOLT project.
- Analyze and interpret experimental data and propose relevant alternative solutions if necessary.
- Present work progress and results in the lab/consortium meetings and at national/international scientific conferences.
- Contribute to the writing of activity reports, scientific publications and grants related to this work.
- Monitor regularly the scientific literature
- Contribute to the training and supervision of students in the laboratory.
We are seeking a highly motivated candidate with a solid background in microbial genetics, microbiology and molecular biology. Experience in the field of mycobacterial genetics will be appreciated. Knowledge and a practical expertise in fluorescence-activated cell sorting (FACS) applied to bacteria will be a plus. Previous work experience and publication record will be considered as an important element during the selection process. Good English communication and an ability to interact socially and scientifically in a multidisciplinary environment will be required.
This postdoctoral project is part of an ANR project which gathers four internationally recognized research teams with multidisciplinary expertise in genetic engineering of mycobacteria, structural biology, proteomics and lipidomics. The hired person will be based at the Institute of Pharmacology and Structural Biology (IPBS, www.ipbs.fr) located in Toulouse (south of France), within the Molecular Mycobacterial Pathogenesis team. He/she will work under the supervision of Christian Chalut, the project coordinator, in close collaboration with the project partners. The IPBS currently hosts 16 research groups working in the fields of cancer, infection and inflammation. The laboratory contains state-of-the art equipment for molecular biology and microbiology projects and houses several technological platforms relevant to the project.
Constraints and risks
Applicants are asked to provide a CV including a list of publications, a cover letter describing research interests, and names and contact details of two referents.
More information about the project: https://anr.fr/Project-ANR-21-CE44-0027
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