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Reference : UMR5031-CORAME0-008
Workplace : PESSAC
Date of publication : Friday, November 30, 2018
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 January 2019
Proportion of work : Full time
Remuneration : 2 500 € gross monthly
Desired level of education : PhD
Experience required : Indifferent
In the framework of the consortium Max Syn Bio, we offer a 12-months Post-doc position.
Max Syn Bio is consortium consisting of 10 partners from Max Planck Institutes in Germany and one partner lab at the Univ. Bordeaux, CNRS, on the them of droplet-based microfluidics for applications in Bottom-up Synthetic Biology. The principle of bottom-up synthetic biology is to mimics in vitro the functions of natural living systems to realise artificial analogs. To properly function, this assembly of function relies on tools for the manipulation of microcompartments at a high-throughput and droplet-based microfluidics here provide the toolbox for these operations.
The objective of the post-doc is to develop microfluidic systems optimised for the assembly of metabolic functions in microcompartments. The project will be realised in collaboration with our partner labs in the network (Tobias Erb, Max Planck Institute Marburg, Dora Tang, Max Planck Institute Dresden) and implies strong interactions with all the members of the network.
The candidate must be interested in a multi-disciplinary approach mixing physics, chemistry, biology and engineering and he must have experience in one of these area. A good level of English is required, as well as good communication skills and reporting capabilities.
The group Soft Micro Systems (SMS) is led by Prof. Jean-Christophe Baret at the Centre de Recherche Paul Pascal (Pessac, F). The research thems of the group encompasses the technologies of microfluidics for applications in biotechnology and synthetic biology
Sequential bottom-up assembly of mechanically stabilized synthetic cells by microfluidics, M. Weiss, J. P. Frohnmayer, L. T. Benk, B. Haller, J.-W. Janiesch, T. Heitkamp, M. Boersch, R. B. Lira, R. Dimova, R. Lipowsky, E. Bodenschatz, J.-C. Baret, T. Vidakovic-Koch, K. Sundmacher, I. Platzman & J. P. Spatz, Nature Materials, 17, 89-96 (2018)
Out-of-equilibrium microcompartments for the bottom-up integration of metabolic functions, T. Beneyton, D. Krafft, C. Bednarz, C. Kleineberg, C. Woelfer, I. Ivanov, T. Vidakovic-Koch, K. Sundmacher and J.-C. Baret, Nature Communications, 9:2391 (2018)
Surfactant adsorption kinetics in microfluidics, B. Riechers, F. Maes, E. Akoury, B. Semin, P. Gruner, and J.-C. Baret, Proceedings of the National Academy of Sciences U.S.A, 113, 41, 11465-11470 (2016)
Controlling molecular transport in minimal emulsions, P. Gruner, B. Riechers, B. Semin, J. Lim, A. Johnston, K. Short, J.-C. Baret, Nature Communications, 10392 (2016)
Ultrahigh-throughput screening in drop-based microfluidics for directed evolution, J. J. Agresti, E. Antipov, A. R. Abate, K. Ahn, A. C. Rowat, J.-C. Baret, M. Marquez, A. M. Klibanov, A. D. Griffiths, and D. A. Weitz, roceedings of the National Academy of Sciences U.S.A 107 (2010) 4004
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