By continuing to browse the site, you are agreeing to our use of cookies. (More details)
Portal > Offres > Offre UMR3664-ANTCOU-003 - Postdoc (H/F) en physique théorique: Dynamique 4D du génome

Postdoc in theoretical physics: 4D genome dynamics

This offer is available in the following languages:
Français - Anglais

Ensure that your candidate profile is correct before applying. Your profile information will be added to the details for each application. In order to increase your visibility on our Careers Portal and allow employers to see your candidate profile, you can upload your CV to our CV library in one click!

Faites connaître cette offre !

General information

Reference : UMR3664-ANTCOU-003
Workplace : PARIS 05
Date of publication : Monday, September 30, 2019
Type of Contract : FTC Scientist
Contract Period : 18 months
Expected date of employment : 13 November 2019
Proportion of work : Full time
Remuneration : Gross monthly salary: 2695,56 – 3841,41 € depending on qualifications and experience
Desired level of education : PhD
Experience required : Indifferent

Missions

Our team “Genome Functions in Space and Time” studies the 3D organization and dynamics of chromosomes in the cell nucleus and its role in regulating gene expression.

We use and develop a panel of single-molecule imaging techniques in both live and fixed cells to image DNA, RNAs and proteins inside the nucleus. Our interdisciplinary group also develops computational tools for data analysis and physical models of the genome and the nucleus.
More info: www.coulonlab.org

You will the specialist of the team in physical modeling and data analysis.

Activities

You will be involved in several projects of the team and will participate by:
• analyzing data from live- and fixed-cell imaging (in collaboration with in engineer in image analysis in the team)
• developing physical models of the studied phenomena in order to interpret experimental results and propose testable hypotheses.

In this context, you will propose modeling and data analysis tools which will also apply to publicly available data.

Project of the team in which you will be involved include:
• 4D tracking of genomic loci (genes, enhancers, genomic domain boundaries, repeat elements) in live cells over a large range of spatial, temporal and genomic scales, as to understand the mechanisms underlying the dynamic organization of chromosomes
• the coordination between the transcriptional activity of genes and their spatial relationship, measured by RNA-imaging techniques in live and fixed cells (MS2/PP7, RNA FISH, Oligopaint/MERFISH), in order to understand the links between the 3D organization of the genome and the regulation of its expression.

Skills

[ *** : required     ** : recommended     * : appreciated ]

*** Ph.D. degree in Physics
** Experience in polymer modeling of genome organization

Advanced skills in:
*** Non-equilibrium statistical physics
*** Mathematics of stochastic processes
** Diffusion in disordered media
** Frequency-domain signal theory

Programming and scientific computing:
*** Python, SciPy
* Parallel/cluster computing (CentOS)
* Notions in bioinformatics (especially Hi-C datasets)

*** Proficiency in English (written, spoken), which is the working language of the group
** Organization skills, autonomy, ability to communicate and present data / results

Work Context

The team is co-affiliated with a biology research unit (Nuclear Dynamics, UMR3664) and a physics research unit (Physical Chemistry, UMR168) at Institut Curie. You will be working in close contact with the experimentalists in the team.

Additional Information

Please apply through this website ('Portail Emploi' of the CNRS) with a cover letter and your CV.

We talk about it on Twitter!