Faites connaître cette offre !
Reference : UMR3664-ANTCOU-003
Workplace : PARIS 05
Date of publication : Monday, September 30, 2019
Type of Contract : FTC Scientist
Contract Period : 18 months
Expected date of employment : 13 November 2019
Proportion of work : Full time
Remuneration : Gross monthly salary: 2695,56 – 3841,41 € depending on qualifications and experience
Desired level of education : PhD
Experience required : Indifferent
Our team “Genome Functions in Space and Time” studies the 3D organization and dynamics of chromosomes in the cell nucleus and its role in regulating gene expression.
We use and develop a panel of single-molecule imaging techniques in both live and fixed cells to image DNA, RNAs and proteins inside the nucleus. Our interdisciplinary group also develops computational tools for data analysis and physical models of the genome and the nucleus.
More info: www.coulonlab.org
You will the specialist of the team in physical modeling and data analysis.
You will be involved in several projects of the team and will participate by:
• analyzing data from live- and fixed-cell imaging (in collaboration with in engineer in image analysis in the team)
• developing physical models of the studied phenomena in order to interpret experimental results and propose testable hypotheses.
In this context, you will propose modeling and data analysis tools which will also apply to publicly available data.
Project of the team in which you will be involved include:
• 4D tracking of genomic loci (genes, enhancers, genomic domain boundaries, repeat elements) in live cells over a large range of spatial, temporal and genomic scales, as to understand the mechanisms underlying the dynamic organization of chromosomes
• the coordination between the transcriptional activity of genes and their spatial relationship, measured by RNA-imaging techniques in live and fixed cells (MS2/PP7, RNA FISH, Oligopaint/MERFISH), in order to understand the links between the 3D organization of the genome and the regulation of its expression.
[ *** : required ** : recommended * : appreciated ]
*** Ph.D. degree in Physics
** Experience in polymer modeling of genome organization
Advanced skills in:
*** Non-equilibrium statistical physics
*** Mathematics of stochastic processes
** Diffusion in disordered media
** Frequency-domain signal theory
Programming and scientific computing:
*** Python, SciPy
* Parallel/cluster computing (CentOS)
* Notions in bioinformatics (especially Hi-C datasets)
*** Proficiency in English (written, spoken), which is the working language of the group
** Organization skills, autonomy, ability to communicate and present data / results
The team is co-affiliated with a biology research unit (Nuclear Dynamics, UMR3664) and a physics research unit (Physical Chemistry, UMR168) at Institut Curie. You will be working in close contact with the experimentalists in the team.
Please apply through this website ('Portail Emploi' of the CNRS) with a cover letter and your CV.
We talk about it on Twitter!